C4680

Sigma-Aldrich

α-Cyclodextrin

powder, BioReagent, suitable for cell culture, ≥98%

Synonym(s):
α-Schardinger dextrin, Cyclomaltohexaose, Cyclohexaamylose
Empirical Formula (Hill Notation):
C36H60O30
CAS Number:
Molecular Weight:
972.84
Beilstein/REAXYS Number:
79627
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

sterility

non-sterile

product line

BioReagent

assay

≥98%

form

powder

application(s)

cell culture | mammalian: suitable

mp

>278 °C (dec.) (lit.)

solubility

H2O: 10 mg/mL

shipped in

ambient

storage temp.

room temp

SMILES string

OCC@H1OC@@H2OC@H3C@H(O)C@@H(O)C@H(OC@@H3CO)OC@H4C@H(O)C@@H(O)C@H(OC@@H4CO)OC@H5C@H(O)C@@H(O)C@H(OC@@H5CO)OC@H6C@H(O)C@@H(O)C@H(OC@@H6CO)OC@H7C@H(O)C@@H(O)C@H(OC@@H7CO)OC@H1C@H(O)C@H2O

InChI

1S/C36H60O30/c37-1-7-25-13(43)19(49)31(55-7)62-26-8(2-38)57-33(21(51)15(26)45)64-28-10(4-40)59-35(23(53)17(28)47)66-30-12(6-42)60-36(24(54)18(30)48)65-29-11(5-41)58-34(22(52)16(29)46)63-27-9(3-39)56-32(61-25)20(50)14(27)44/h7-54H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-/m1/s1

InChI key

HFHDHCJBZVLPGP-RWMJIURBSA-N

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General description

α-Cyclodextrin (α-CD) is a cyclic oligosaccharide that consists of six glucopyranose units linked by α-(1,4) bonds. α-CD acts as a soluble dietary fiber and hence it is preferred to be widely used in food industry.

Application

Useful for the solubilization of nonpolar macromolecules such as fatty acids, lipids, and cholesterol for use in cell culture applications. α-Cyclodextrin has been used to solubilize odanacatib, a cathepsin K inhibitor.

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

α-Cyclodextrin is found to form a firm complex with dietary fats. This way it decreases the bioavailability and absorption of fats. It is known to regulate triglyceride and leptin levels in serum. In rat models, α-Cyclodextrin is shown to induce insulin sensitivity and fecal fat excretion. Thus, α-cyclodextrin is considered to be effective for treating obesity and metabolic syndromes.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Functional Carbohydrates: Development, Characterization, and Biomanufacture (2017)
Pulsed low-dose RANKL as a potential therapeutic for postmenopausal osteoporosis
Cline SA, et al.
JCI insight, 1(13) (2016)
The Beneficial Effects a-Cyclodextrin on Blood Lipids and Weight Loss in Healthy Humans
Comerford KB, et al
Obesity (Silver Spring, Md.), 19(6), 1200-1204 (2011)
Yuya Hayashi et al.
Molecular pharmaceutics, 9(6), 1645-1653 (2012-04-19)
To reveal the potential use of lactosylated-dendrimer (G3) conjugates with α-cyclodextrin (Lac-α-CDE (G3)) as novel hepatocyte-specific siRNA carriers in order to treat transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP), we evaluated the RNAi effect of siRNA complexes with Lac-α-CDE (G3) both...
M C Hamoudi et al.
Journal of controlled release : official journal of the Controlled Release Society, 161(3), 861-867 (2012-05-29)
The purpose of this work was to investigate the potential of α-cyclodextrin combined to soybean oil-based formulations to modulate the release of a model drug, indomethacin. Dry emulsion, naked and coated beads were prepared from the same initial formulation using...
Articles
Solubility of common cell culture components in water and in a solution of 2-Hydroxylpropyl beta-cyclodextrin. Cyclodextrin is a non-toxic compound useful for its ability to solubilize fat soluble vitamins and hormones.
Read More
Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds in tissue culture, cell culture, or other water-based applications.
Read More

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