Documents

D1056

Sigma-Aldrich

N2,N2-Dimethylguanosine

Empirical Formula (Hill Notation):
C12H17N5O5
CAS Number:
Molecular Weight:
311.29
MDL number:

storage temp.

2-8°C

SMILES string

CN(C)C1=Nc2c(ncn2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1

Application

Proposed as an indicator for tRNA half-life in normal vs. cancerous tissues.

Other Notes

Modified nucleoside found in tRNA and snRNA of archaebacteria and eukaryotes.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis

Certificate of Origin

K Nakano et al.
Clinica chimica acta; international journal of clinical chemistry, 218(2), 169-183 (1993-09-30)
Using boronate gel affinity chromatography and reversed-phase high-performance liquid chromatography (RP-HPLC), a method for the simultaneous determination of 12 urinary modified nucleosides has been developed. The RP-HPLC fractions were identified by gas chromatography/mass spectrometry analysis. The HPLC quantitation of urinary...
C G Edmonds et al.
Journal of bacteriology, 173(10), 3138-3148 (1991-05-01)
Nucleoside modification has been studied in unfractionated tRNA from 11 thermophilic archaea (archaebacteria), including phylogenetically diverse representatives of thermophilic methanogens and sulfur-metabolizing hyperthermophiles which grow optimally in the temperature range of 56 (Thermoplasma acidophilum) to 105 degrees C (Pyrodictium occultum)...
Akiko Ogawa et al.
Molecular cell, 81(4), 659-674 (2021-01-21)
About 150 post-transcriptional RNA modifications have been identified in all kingdoms of life. During RNA catabolism, most modified nucleosides are resistant to degradation and are released into the extracellular space. In this study, we explored the physiological role of these...

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