D5821

Sigma-Aldrich

DS2

≥98% (HPLC)

Empirical Formula (Hill Notation):
C18H12ClN3OS
CAS Number:
Molecular Weight:
353.83
MDL number:
PubChem Substance ID:

assay

≥98% (HPLC)

form

powder

color

off-white to light tan

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Clc1ccc(cc1)C(=O)Nc2c(nc3ccccn23)-c4cccs4

InChI

1S/C18H12ClN3OS/c19-13-8-6-12(7-9-13)18(23)21-17-16(14-4-3-11-24-14)20-15-5-1-2-10-22(15)17/h1-11H,(H,21,23)

InChI key

AZKMWHRDICVYEI-UHFFFAOYSA-N

Biochem/physiol Actions

DS2 is a selective positive allosteric modulator of δ-GABAA receptors.

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Certificate of Analysis
Certificate of Origin
Wing Sun Faith Chung et al.
BMC biology, 14, 3-3 (2016-01-13)
Dietary intake of specific non-digestible carbohydrates (including prebiotics) is increasingly seen as a highly effective approach for manipulating the composition and activities of the human gut microbiota to benefit health. Nevertheless, surprisingly little is known about the global response of...
Julianne Megaw et al.
Frontiers in microbiology, 8, 1589-1589 (2017-09-06)
Persister cells are phenotypic variants within a microbial population, which are dormant and transiently tolerant to stress. Persistence has been studied extensively in bacteria, and in eukaryotes to a limited extent, however, it has never been observed in archaea. Using...
Sjoukje-Marije Haisma et al.
PloS one, 14(4), e0214751-e0214751 (2019-04-19)
Treatment decisions in inflammatory bowel diseases are increasingly based on longitudinal tracking of calprotectin results. Many hospital laboratories measure calprotectin levels in sent-in stool samples with an enzyme-linked immunosorbent assay (ELISA). Several manufacturers introduced a lateral flow-based test with software...
Lia Mesbah-Oskui et al.
Anesthesiology, 125(5), 964-978 (2016-10-19)
Alterations in thalamic γ-aminobutyric acid-mediated signaling are thought to underlie the increased frontal α-β frequency electrocortical activity that signals anesthetic-induced loss of consciousness with γ-aminobutyric acid receptor type A (GABAAR)-targeting general anesthetics. The general anesthetic etomidate elicits phasic extrasynaptic GABAAR...
Yongchang Zheng et al.
Briefings in bioinformatics, 19(1), 101-108 (2016-10-21)
The alteration of DNA methylation landscape is a key epigenetic event in cancer. As the accumulation of large-scale genome-wide DNA methylation data from clinical samples, we are able to characterize the patterns of DNA methylation alterations for identifying candidate epigenetic...

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