D7159

Sigma-Aldrich

2′,3′-Dideoxycytidine 5′-triphosphate sodium salt

≥90% (HPLC)

Synonym(s):
ddCTP
Empirical Formula (Hill Notation):
C9H16N3O12P3
CAS Number:
Molecular Weight:
451.16
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

biological source

synthetic (organic)

assay

≥90% (HPLC)

form

powder

solubility

water: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2

InChI

1S/C9H16N3O12P3.Na/c10-7-3-4-12(9(13)11-7)8-2-1-6(22-8)5-21-26(17,18)24-27(19,20)23-25(14,15)16;/h3-4,6,8H,1-2,5H2,(H,17,18)(H,19,20)(H2,10,11,13)(H2,14,15,16);/q;+1/p-1/t6-,8+;/m0./s1

InChI key

LOOMQRBEBYCFPP-QDOHZIMISA-M

Packaging

1, 2 mg in glass bottle

Application

Complexes of ddCTP with DNA polymerase β were studied by x-ray crystallography, with implications for inhibitory activity against HIV reverse transcriptase.

Biochem/physiol Actions

Inhibitor of DNA polymerase I-catalyzed chain elongation.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Georges Massiot et al.
Journal of natural products, 68(7), 979-984 (2005-07-26)
Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl...
Yaligara Veeranagouda et al.
BMC genomics, 15, 429-429 (2014-06-06)
Bacteroides fragilis is a Gram-negative anaerobe that is normally a human gut commensal; it comprises a small percentage of the gut Bacteroides but is the most frequently isolated Bacteroides from human infections. Identification of the essential genes necessary for the...
Michal R Szymanski et al.
The EMBO journal, 34(14), 1959-1970 (2015-06-10)
The human DNA polymerase gamma (Pol γ) is responsible for DNA replication in mitochondria. Pol γ is particularly susceptible to inhibition by dideoxynucleoside-based inhibitors designed to fight viral infection. Here, we report crystal structures of the replicating Pol γ-DNA complex...
Nutjaree Jeenduang et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 36-43 (2015-01-17)
Cardiovascular disease (CVD) is one of the major causes of death worldwide. Numerous genetic risk factors in lipid metabolism, including mutations of LDLR, APOB, and PCSK9, as well as polymorphisms of CETP and APOE, have been found to associate with...

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