R(−)-Fenfluramine hydrochloride

Empirical Formula (Hill Notation):
C12H16F3N · HCl
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:

drug control

USDEA Schedule IV

SMILES string




InChI key


Biochem/physiol Actions

Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic.
Less active enantiomer


Skull and crossbones

Signal Word


Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN 2811 6.1 / PGIII

WGK Germany


Recent studies in the clinical pharmacology of anorectic drugs.
Silverstone, et al.
Recent Adv. Obes. Res., 5, 285-285 (1986)
Re: Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Nicolas Deltour et al.
Pharmacoepidemiology and drug safety, 21(6), 584-585 (2012-04-21)
Benfluorex-induced cardiac valve injury.
Jean Acar
Pharmacoepidemiology and drug safety, 21(11), 1243-1244 (2012-10-31)
Shoko Sato et al.
Biological & pharmaceutical bulletin, 35(10), 1697-1702 (2012-08-02)
We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)(1A)...
Laurent Savale et al.
The European respiratory journal, 40(5), 1164-1172 (2012-04-24)
Benfluorex was marketed in France until 2009, despite its similar pharmacological properties with fenfluramine and its derivatives known to be a cause of pulmonary arterial hypertension (PAH). The aim of this study is to report clinical and haemodynamic characteristics for...

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