G0923

Sigma-Aldrich

Golgicide A

≥98% (HPLC)

Synonym(s):
CID 25113626, GCA, 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Empirical Formula (Hill Notation):
C17H14F2N2
CAS Number:
Molecular Weight:
284.30
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4

InChI

1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1

InChI key

NJZHEQOUHLZCOX-FTLRAWMYSA-N

Application

Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Onya Opota et al.
Microbes and infection, 19(11), 546-552 (2017-08-15)
Kingella kingae, producing the cytotoxic RTX protein, is a causative agent of serious infections in humans such as bacteremia, endocarditis and osteoarticular infection, especially in young children. Recently, Kingella negevensis, a related species, has been isolated from the oral cavity...
A conserved role for the ESCRT membrane budding complex in LINE retrotransposition.
Horn AV, et al.
PLoS Genetics, 13(6), e1006837-e1006837 (2017)
ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration.
Chia J, et al.
eLife, 3(6), e01828-e01828 (2014)
Hélène Gingras et al.
Microbial genomics, 4(2) (2018-01-11)
In order to expedite the discovery of genes coding for either drug targets or antibiotic resistance, we have developed a functional genomic strategy termed Plas-Seq. This technique involves coupling a multicopy suppressor library to next-generation sequencing. We generated an Escherichia...
Danelle K Seymour et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7317-E7326 (2016-11-03)
The ubiquity of nonparental hybrid phenotypes, such as hybrid vigor and hybrid inferiority, has interested biologists for over a century and is of considerable agricultural importance. Although examples of both phenomena have been subject to intense investigation, no general model...
Related Content
Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.
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