H3129

Sigma-Aldrich

His-Ser

Synonym(s):
histidylserine
Empirical Formula (Hill Notation):
C9H14N4O4
CAS Number:
Molecular Weight:
242.23
MDL number:
PubChem Substance ID:
NACRES:
NA.26

assay

≥98% (TLC)

Quality Level

form

powder

application(s)

ligand binding assay: suitable

color

white to faint yellow

storage temp.

−20°C

SMILES string

NC(Cc1cnc[nH]1)C(=O)NC(CO)C(O)=O

InChI

1S/C9H14N4O4/c10-6(1-5-2-11-4-12-5)8(15)13-7(3-14)9(16)17/h2,4,6-7,14H,1,3,10H2,(H,11,12)(H,13,15)(H,16,17)

InChI key

KRBMQYPTDYSENE-UHFFFAOYSA-N

Biochem/physiol Actions

Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Pulimamidi R Reddy et al.
Chemistry & biodiversity, 2(5), 672-683 (2006-12-29)
A series of Zn(II) complexes with cysteinylglycine (CysGly) and histidylserine (HisSer), and of CysGly and histidylphenylalanine (HisPhe) were investigated. Complex stabilities were determined potentiometrically, and binding geometries were probed by means of 1H-NMR spectroscopy, using Co(II) instead of Zn(II) as...
Carl Henrik Görbitz
Acta crystallographica. Section C, Crystal structure communications, 66(Pt 11), o531-o534 (2010-11-06)
Dipeptides may form nanotubular structures with pore diameters in the range 3.2-10 Å. These compounds normally contain at least one and usually two hydrophobic residues, but L-His-L-Ser hydrate, C(9)H(14)N(4)O(4)·3.7H(2)O, with two hydrophilic residues, forms large polar channels filled with ordered as...
Pulimamidi R Reddy et al.
Chemistry & biodiversity, 2(10), 1338-1350 (2006-12-29)
Stable Cu(II) complexes with histamine- and histidine-containing dipeptides histidylserine and histidylphenylalanine have been developed. Their interaction in solution has been investigated, and the stability of their complexes was determined. The nature of binding in these complexes has been explained with...
Pulimamidi R Reddy et al.
Chemistry & biodiversity, 1(6), 839-853 (2006-12-29)
Copper(II) complexes are known to play a significant role in both naturally occurring biological systems and pharmaceutical agents. Recently, Cu(II) complexes have gained importance in DNA cleavage essential for the development of anticancer drugs and chemotherapeutic agents. Therefore, we have...
Pulimamidi R Reddy et al.
Chemistry & biodiversity, 3(2), 231-244 (2006-12-29)
A series of small model complexes made from Ni(II) and the ligands ethylenediamine (en), histamine (hist), and histidylleucine (HisLeu) were prepared and studied as potential hydrolytic DNA-cleavage agents. The stability constants and species-distribution curves for these complexes were determined as...

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