MilliporeSigma
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I151

Sigma-Aldrich

Indomethacin morpholinylamide

solid

All Photos(1)
Synonym(s):
BML-190, N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine
Empirical Formula (Hill Notation):
C23H23ClN2O4
Molecular Weight:
426.89
MDL number:
MFCD01317813
PubChem Substance ID:
329815352

form

solid

color

off-white

solubility

DMSO: >20 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

COc1ccc2n(c(C)c(CC(=O)N3CCOCC3)c2c1)C(=O)c4ccc(Cl)cc4

InChI

1S/C23H23ClN2O4/c1-15-19(14-22(27)25-9-11-30-12-10-25)20-13-18(29-2)7-8-21(20)26(15)23(28)16-3-5-17(24)6-4-16/h3-8,13H,9-12,14H2,1-2H3

InChI key

BJSDNVVWJYDOLK-UHFFFAOYSA-N

Gene Information

human ... CNR2(1269)

Biochem/physiol Actions

CB2 cannabinoid receptor agonist.

Certificate of Analysis

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Certificate of Origin

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E Romeo et al.
The Journal of pharmacology and experimental therapeutics, 262(3), 971-978 (1992-09-01)
The 2 aryl-3-indoleacetamides (FGIN-1) are a new class of compounds that potently (nM) and selectively bind to glial mitochondrial diazepam binding inhibitor (DBI) receptors (MDR), previously called peripheral benzodiazepine receptors, and increase mitochondrial steroidogenesis. The high-affinity binding of FGIN-1 to
Pretal P Muldoon et al.
Neuropharmacology, 176, 108170-108170 (2020-06-02)
Nicotine, the primary psychoactive component in tobacco, plays a major role in the initiation and maintenance of tobacco dependence and addiction, a leading cause of preventable death worldwide. An essential need thus exists for more effective pharmacotherapies for nicotine-use cessation.

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