I1761

Sigma-Aldrich

Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in goat

whole antiserum

MDL number:
NACRES:
NA.46
Pricing and availability is not currently available.

biological source

goat

antibody form

whole antiserum

antibody product type

secondary antibodies

clone

polyclonal

contains

15 mM sodium azide

application(s)

immunoelectrophoresis: suitable

conjugate

unconjugated

shipped in

dry ice

storage temp.

−20°C

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General description

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. IgG is usually found as a monomer. IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. About 70 percent of the total immunoglobulin consists of IgG. Immunoglobulin M (IgM ) is a high molecular weight protein that has five or six subunits. Human serum shows low concentration of IgM monomers. It has a high carbohydrate content of about 12%. It is the first immunoglobulin produced by neonates.

Specificity

The antiserum is determined to be immunospecific for human IgG, IgA and IgM. Reactivity is also observed against light chains.

Application

Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in goat has been used in immunoassays/sandwich immunoassay and enzyme-linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Immunoglobulin G (IgG) participates in hypersensitivity type II and type III. Immunoglobulin M (IgM) acts as an antigen specific part of the B cell antigen receptor on the surface of B lymphocytes that are not stimulated, in its monomeric form. Polymeric IgM molecules also serve as important activators of the classical complement cascade. IgM is essential in agglutination and cytolytic reactions.
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections. IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. IgM antibodies are present as pentamers in the serum and are produced in response to antigens.

Physical form

The antibody is supplied as a liquid containing 0.1% sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xn

Risk Statement

22

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Molecular Genetics of Immunoglobulin, 17 (1987)
High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells
Jager V, et al.
BMC biotechnology, 13(1), 52-52 (2013)
The Immunoglobulins: Structure and Function (1998)
Volker Jäger et al.
BMC biotechnology, 13, 52-52 (2013-06-28)
The demand of monospecific high affinity binding reagents, particularly monoclonal antibodies, has been steadily increasing over the last years. Enhanced throughput of antibody generation has been addressed by optimizing in vitro selection using phage display which moved the major bottleneck...
Douglas B Weibel et al.
Analytical chemistry, 77(15), 4726-4733 (2005-08-02)
This paper describes torque-actuated valves for controlling the flow of fluids in microfluidic channels. The valves consist of small machine screws (> or =500 microm) embedded in a layer of polyurethane cast above microfluidic channels fabricated in poly(dimethylsiloxane) (PDMS). The...

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