Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells
Zhang Y et al
Journal of Interferon Research, 30, 113-122 (2010)
Geoffroy Laumet et al.
Pain, 161(10), 2344-2352 (2020-05-20)
Understanding the mechanisms that drive transition from acute to chronic pain is essential to identify new therapeutic targets. The importance of endogenous resolution pathways acting as a "brake" to prevent development of chronic pain has been largely ignored. We examined...
Ivan J Fuss et al.
Journal of immunology (Baltimore, Md. : 1950), 168(2), 900-908 (2002-01-05)
In the present study, we define the relation between TGF-beta and IL-10 in the regulation of the Th1-mediated inflammation occurring in trinitrobenzene sulfonic acid (TNBS)-colitis. In initial studies, we showed that the feeding of trinitrophenol-haptenated colonic protein to SJL/J mice...
Christian M Hedrich et al.
Immunologic research, 47(1-3), 185-206 (2010-01-21)
IL-10 plays an essential part in controlling inflammation and instructing adaptive immune responses. Consequently, dysregulation of IL-10 is linked with susceptibility to numerous infectious and autoimmune diseases in mouse models and in humans. It has become increasingly clear that appropriate...
Joshua C Cyktor et al.
Infection and immunity, 79(8), 2964-2973 (2011-05-18)
The generation of an effective immune response against an infection while also limiting tissue damage requires a delicate balance between pro- and anti-inflammatory responses. Interleukin-10 (IL-10) has potent immunosuppressive effects and is essential for regulation of immune responses. However, the...