K1879

Sigma-Aldrich

Kinetensin

≥97% (HPLC)

Linear Formula:
Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu
CAS Number:
Molecular Weight:
1172.38
MDL number:

assay

≥97% (HPLC)

composition

Peptide content, ~70%

storage temp.

−20°C

SMILES string

[H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CC(C)C)C(O)=O

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Amino Acid Sequence

Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu

Biochem/physiol Actions

Neurotensin-related peptide which appears in human plasma treated with pepsin; increases vascular permeability and releases histamine from rat mast cells.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis

Certificate of Origin

D Read et al.
Agents and actions, 38(3-4), 231-239 (1993-03-01)
Kinetensin is a nonapeptide, originally isolated from pepsin-treated plasma, that shares some sequence homology with the C-terminal end of neurotensin. The present study was designed to determine, by infusing kinetensin to conscious sheep, the pharmacokinetics and a neurotensin-like biological activity...
A Sydbom et al.
Agents and actions, 27(1-2), 68-71 (1989-04-01)
The peptide kinetensin isolated from pepsin-treated human plasma induced a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration was around 10(-6) M, the ED50 was 10(-5) M, and the optimal concentration of between 10(-4)...
M H Mogard et al.
Biochemical and biophysical research communications, 136(3), 983-988 (1986-05-14)
A novel nonapeptide with neurotensin-like immunoreactivity was isolated from pepsin-treated human plasma by dialysis, ion-exchange chromatography and high performance reversed-phase liquid chromatography. The amino acid sequence was determined by automated gas-phase sequence analysis as Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu. Sequence homology with human serum...

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