K3000

Sigma-Aldrich

Kinetin riboside

proapoptotic anitproliferative plant growth regulator

Synonym(s):
6-Furfurylaminopurine riboside, N6-(2-Furanyl­methyl)adenosine, N6-Furfuryladenosine
Empirical Formula (Hill Notation):
C15H17N5O5
CAS Number:
Molecular Weight:
347.33
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.72
Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)
≥98% (TLC)

form

powder

solubility

acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow

storage temp.

2-8°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23

InChI

1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1

InChI key

CAGLGYNQQSIUGX-SDBHATRESA-N

Gene Information

rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

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Related Categories

Packaging

5, 100 g in glass bottle

Biochem/physiol Actions

Kinetin riboside, a cytokinin riboside plant hormone with anticancer activity, has been used to study differentiation and apoptosis processes in myeloid leukemia cells, plant tumor cells (crown-gall) and other cancers.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Yuki Ishii et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 13(1), 19-26 (2002-01-22)
We examined the effects of various adenine analogues on the growth and differentiation of human myeloid leukemia HL-60 cells. Some of these analogues inhibit growth and induce nitroblue tetrazolium reducing activity in HL-60 cells. Cytokinins such as kinetin, isopentenyladenine, and...
Effects of kinetin riboside on proliferation and proapoptotic activities in human normal and cancer cell lines.
Dudzik P, Dulinska-Litewka J, Wyszko E, et al.
The Journal of Cell Biology, 112, 2115-2124 (2011)
Michael Webb et al.
Bioorganic & medicinal chemistry letters, 29(11), 1270-1277 (2019-04-08)
Mitochondrial dysfunction is a causative and/or exacerbating feature of many pathologies. We discuss below approaches to modulate mitochondrial dysfunction that involve (1) increasing their energetic efficiency by targeting gene expression regulators such as PPAR or AMPK, (2) using antioxidant compounds...
Zhenfang Cheng et al.
Journal of separation science, 41(11), 2386-2392 (2018-02-24)
In this work, an easy, effective, and sensitive method based on graphene oxide@silica@magnetite composites as adsorbent of magnetic solid-phase extraction combined with liquid chromatography and tandem mass spectrometry, was established and validated for the trace analysis of cytokinins in different...
Bo-Hwa Choi et al.
Cancer letters, 261(1), 37-45 (2007-12-29)
Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while...

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