M2383

Sigma-Aldrich

α-(Methylamino)isobutyric acid

≥97% (titration)

Synonym(s):
2,N-Dimethylalanine, 2-(Methylamino)-2-methylpropionic acid
Linear Formula:
CH3NHC(CH3)2COOH
CAS Number:
Molecular Weight:
117.15
Beilstein/REAXYS Number:
1746984
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26
Pricing and availability is not currently available.

Quality Level

assay

≥97% (titration)

form

powder

application(s)

ligand binding assay: suitable

color

white

mp

>300 °C (lit.)

storage temp.

−20°C

SMILES string

CNC(C)(C)C(O)=O

InChI

1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8)

InChI key

DLAMVQGYEVKIRE-UHFFFAOYSA-N

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Related Categories

Packaging

250 mg in poly bottle
1 g in poly bottle

Biochem/physiol Actions

α-(Methylamino)isobutyric acid is a competitive inhibitor of the neutral amino acid transport A system.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Differentiation of tumour and inflammation: characterisation of [methyl-3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells
Barbara Stober et al.
European Journal of Nuclear Medicine, 33, 932-939 (2006)
J R Bading et al.
Nuclear medicine and biology, 23(6), 779-786 (1996-08-01)
The A system of amino acid transport is concentrative and thought to be a regulator of cell growth. The [11C]methyl alpha-aminoisobutyric acid (MeAIB) is prospectively an ideal tracer for transport measurements with PET, as it is not metabolized and concentrates...
Nora Sandow et al.
Epilepsia, 50(4), 849-858 (2009-01-30)
Glutamine (GLN) is a precursor for synthesis of glutamate and gamma-aminobutyric acid (GABA) and has been found in the cerebrospinal fluid (CSF) at mean concentrations of 0.6 mM. Experiments on slices are usually performed in artificial CSF (aCSF) kept free...
Ralf Bergmann et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 45(12), 2116-2122 (2004-12-09)
(18)F-Labeled amino acids represent a promising class of imaging agents in tumors, particularly brain tumors. However, the determination of their potential to image peripheral tumors, possibly depending on individual transport characteristics, still remains an area of investigation. The present study...
Sílvia Busquets et al.
International journal of molecular medicine, 16(3), 471-476 (2005-08-04)
Incubation of rat isolated skeletal muscles (extensor digitorum longus) in the presence of 100 ng/ml of human recombinant interleukin-15 (IL-15) resulted in a significant decrease in total proteolytic rate, while it had no effect on total protein synthesis as measured...

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