M5154

Sigma-Aldrich

Moxisylyte hydrochloride

>99% (TLC), powder

Synonym(s):
4-(2-Dimethylaminoethoxy)-5-isopropyl-2-methylphenyl acetate hydrochloride
Empirical Formula (Hill Notation):
C16H25NO3 · HCl
CAS Number:
Molecular Weight:
315.84
EC Number:
MDL number:
PubChem Substance ID:

assay

>99% (TLC)

form

powder

color

off-white

solubility

ethanol: 50 mg/mL

SMILES string

Cl.CC(C)c1cc(OC(C)=O)c(C)cc1OCCN(C)C

InChI

1S/C16H25NO3.ClH/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6;/h9-11H,7-8H2,1-6H3;1H

InChI key

IPWGSXZCDPTDEH-UHFFFAOYSA-N

Biochem/physiol Actions

α1-adrenoceptor antagonist; peripheral vasodilator.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

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Certificate of Analysis

Certificate of Origin

R Sakakibara et al.
Journal of the autonomic nervous system, 79(2-3), 191-195 (2000-03-04)
Lower urinary tract dysfunction is a major cause of morbidity in patients with multiple system atrophy (MSA). alpha1-Adrenergic receptors are present in the proximal urethra where impaired relaxation may be responsible for voiding difficulty and a large amount of residual...
C Marquer et al.
Fundamental & clinical pharmacology, 12(4), 377-387 (1998-08-26)
Moxisylyte is a competitive noradrenaline antagonist, acting preferentially on post-synaptic alpha-1 adrenoceptors. It was introduced more than thirty years ago for the treatment of cerebro-vascular disorders and shown more recently effective in the urological field due to its ability to...

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