N1627

Sigma-Aldrich

4-Nitrophenyl β-D-glucuronide

≥98% (TLC)

Synonym(s):
4-Nitrophenyl-β-D-glucopyranosiduronic acid, PNPG
Empirical Formula (Hill Notation):
C12H13NO9
CAS Number:
Molecular Weight:
315.23
Beilstein/REAXYS Number:
1438576
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.52

Quality Level

grade

for molecular biology

assay

≥98% (TLC)

form

powder

solubility

H2O: soluble 100 mg/mL, clear

storage temp.

−20°C

SMILES string

O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H]1O)C(O)=O)Oc2ccc(cc2)[N+]([O-])=O

InChI

1S/C12H13NO9/c14-7-8(15)10(11(17)18)22-12(9(7)16)21-6-3-1-5(2-4-6)13(19)20/h1-4,7-10,12,14-16H,(H,17,18)/t7-,8-,9+,10-,12+/m0/s1

InChI key

QSUILVWOWLUOEU-GOVZDWNOSA-N

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Application

4-Nitrophenyl β-D-glucuronide has been used as substrate in acetate buffer to measure β-glucuronidase.

Packaging

1, 2 g in poly bottle
25, 50, 100, 250 mg in poly bottle

Substrates

Chromogenic substrate for β-glucuronidase (GUS) gene detection.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Analysis of Fluorescent Compounds in Urine by Liquid Chromatography
T. Hanaia & J. Huberta
Journal of Liquid Chromatography, 7, 1627-1642 (1984)
E S Piruzian et al.
Molecular genetics and genomics : MGG, 266(5), 778-786 (2002-01-26)
The coding region of the licB gene from Clostridium thermocellum was truncated at the 3' end. The modified lichenase encoded by the construct (LicBM2) retained the most important properties of the enzyme - its high activity and thermostability. LicBM2 consists...
C F Franssen et al.
Journal of the American Society of Nephrology : JASN, 10(7), 1506-1515 (1999-07-15)
Previously, it was found that patients with necrotizing crescentic glomerulonephritis (NCGN) and anti-neutrophil cytoplasmic autoantibodies (ANCA) directed against proteinase 3 (anti-PR3) had a faster deterioration of renal function and more active renal vasculitic lesions than patients with ANCA directed against...
beta-N-Cyanoethyl acyl hydrazide derivatives: A new class of beta-glucuronidase inhibitors
Khan KM, et al.
Chemical & Pharmaceutical Bulletin, 50(11), 1443-1446 (2002)
A tool for monitoring Trichoderma harzianum: II. The use of a GUS transformant for ecological studies in the rhizosphere
Green Helge and Jensen D Funck
Phytopathology, 85(11), 1436-1440 (1995)
Articles
Drug conjugate analysis and the enzymatic hydrolysis of glucuronides
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