All Photos(1)

N4786

Sigma-Aldrich

NPS 2390

≥99% (HPLC), solid

Synonym(s):
Quinoxaline-2-carboxylic acid adamantan-1-ylamide
Empirical Formula (Hill Notation):
C19H21ON3
CAS Number:
Molecular Weight:
307.39
MDL number:
PubChem Substance ID:

description

Caution-Not Yet Fully Tested-For Research Use Only-Not For Human Use.

assay

≥99% (HPLC)

form

solid

color

white

solubility

DMSO: soluble ~5 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

O=C(NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2)c4cnc5ccccc5n4

InChI

1S/C19H21N3O/c23-18(17-11-20-15-3-1-2-4-16(15)21-17)22-19-8-12-5-13(9-19)7-14(6-12)10-19/h1-4,11-14H,5-10H2,(H,22,23)/t12-,13+,14-,19-

InChI key

ZKFVOZCCAXQXBU-KRFSREQESA-N

Biochem/physiol Actions

Type I metabotropic glutamate receptor antagonist

Legal Information

Sold with the permission of NPS Pharmaceuticals, Inc. striclty for in vitro use only.

Certificate of Analysis

Certificate of Origin

Structure-activity relationship studies of NPS 2390: A potent and selective group I metabotropic glutamate receptor antagonist.
Van Wagenen, B.C., et al.
Abstr. Soc. Neurosci, #618.3 (2000)
Nicola Antonio Martino et al.
PloS one, 6(3), e17714-e17714 (2011-03-26)
The present study investigates the effects of high external calcium concentration ([Ca(2+)](o)) and the calcimimetic NPS R-467, a known calcium-sensing receptor (CaSR) agonist, on growth/proliferation of two equine size-sieved umbilical cord matrix mesenchymal stem cell (eUCM-MSC) lines. The involvement of...
Charalambos Kaittanis et al.
The Journal of experimental medicine, 215(1), 159-175 (2017-11-17)
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in...
Nicola Antonio Martino et al.
PloS one, 9(11), e111533-e111533 (2014-11-08)
Umbilical cord matrix mesenchymal stem cells (UCM-MSCs) present a wide range of potential therapeutical applications. The extracellular calcium-sensing receptor (CaSR) regulates physiological and pathological processes. We investigated, in a large animal model, the involvement of CaSR in triggering osteogenic and...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service