P0041

Sigma-Aldrich

PF-750

≥98% (HPLC)

Synonym(s):
N-Phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide
Empirical Formula (Hill Notation):
C22H23N3O
CAS Number:
Molecular Weight:
345.44
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

O=C(Nc1ccccc1)N2CCC(CC2)Cc3cnc4ccccc4c3

InChI

1S/C22H23N3O/c26-22(24-20-7-2-1-3-8-20)25-12-10-17(11-13-25)14-18-15-19-6-4-5-9-21(19)23-16-18/h1-9,15-17H,10-14H2,(H,24,26)

InChI key

BIODYGOZWZNCAG-UHFFFAOYSA-N

Packaging

5 mg in glass bottle

Biochem/physiol Actions

PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. PF-750 shows 10-fold better potency than URB597 (Sigma# U4133) after 30 min preincubation. PF-750 is highly selective on FAAH. Even at as high as 500 μM, it had no interactions with many tested enzymes, but URB597 and other known FAAH inhibitors did not perform well at low concentraction (100 μM).

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Certificate of Analysis

Certificate of Origin

Articles
We offer many products related to cannabinoid receptors for your research needs.
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service