P7081

Sigma-Aldrich

1,2-Didecanoyl-sn-glycero-3-phosphocholine

≥99% (TLC)

Synonym(s):
Didecanoyllecithin, 3-sn-Phosphatidylcholine, 1,2-didecanoyl, (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxodecyl)oxy]-3,5,9-trioxa-4-phosphanonadecan-1-aminium 4-oxide, inner salt, PC, PC(10:0/10:0), 1,2-Dicaprinoyl-sn-glycero-3-phosphocholine, L-α-Phosphatidylcholine, didecanoyl
Empirical Formula (Hill Notation):
C28H56NO8P
CAS Number:
Molecular Weight:
565.72
Beilstein/REAXYS Number:
3757665
MDL number:
PubChem Substance ID:

Quality Level

assay

≥99% (TLC)

form

powder

functional group

phospholipid

shipped in

ambient

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O)=O

InChI

1S/C28H56NO8P/c1-6-8-10-12-14-16-18-20-27(30)34-24-26(25-36-38(32,33)35-23-22-29(3,4)5)37-28(31)21-19-17-15-13-11-9-7-2/h26H,6-25H2,1-5H3/t26-/m1/s1

InChI key

MLKLDGSYMHFAOC-AREMUKBSSA-N

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RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Cécile Loudet et al.
Biochimica et biophysica acta, 1724(3), 315-323 (2005-06-18)
Mixtures of dicaproyl- (DC), dimyristoyl- (DM) and 1-tetradecanoyl-2-biphenylbutanoyl-(TBB) phosphatidylcholine (PC) in water produce bicelle membranes that are oriented by magnetic fields. DMPC/DCPC systems orient such that their membrane plane is parallel to the magnetic field, whereas for TBBPC/DCPC, the plane...
Vivek S Purohit et al.
The AAPS journal, 8(2), E362-E370 (2006-06-27)
Replacement therapy with exogenous recombinant factor VIII (rFVIII) to control bleeding episodes results in the development of inhibitory antibodies in 15% to 30% of hemophilia A patients. The inhibitory antibodies are mainly directed against specific and universal immunodominant epitopes located...
C Agerholm et al.
Journal of pharmaceutical sciences, 83(12), 1706-1711 (1994-12-01)
The transepithelial transport of biosynthetic human growth hormone (hGH) formulated with the absorption enhancers didecanoyl-L-alpha-phosphatidylcholine (DDPC) and alpha-cyclodextrin (alpha-CD) was studied after intranasal administration to rabbits. Plasma concentrations of the hormone were determined until 240 min post administration by ELISA...
C Vermehren et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(9), 1083-1088 (1997-10-06)
The absorption enhancer, didecanoylphosphatidylcholine (DDPC), improves the nasal absorption of human growth hormone in rabbits. We elucidated the uptake and the metabolism of 1,2-di[1-14C]decanoyl-L-3-phosphatidylcholine and 1,2-didecanoyl-L-3-phosphatidyl[N-methyl-3H]choline in rabbit nasal mucosa in vivo. One minute after nasal application of DDPC, 4.4-7.5%...
Studies on the complex formed between glucagon and dicaprylphosphatidylcholine.
J R Ernandes et al.
Biochimica et biophysica acta, 733(1), 75-86 (1983-08-24)

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