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R9154

Sigma-Aldrich

Ro 106-9920

≥98% (HPLC), solid

Synonym(s):
Tetrazolopyridazine-phenylsulfoxide
Empirical Formula (Hill Notation):
C10H7N5OS
CAS Number:
Molecular Weight:
245.26
MDL number:
PubChem Substance ID:

assay

≥98% (HPLC)

form

solid

solubility

DMSO: 12 mg/mL

storage temp.

−20°C

SMILES string

O=S(c1ccccc1)c2ccc3nnnn3n2

Biochem/physiol Actions

Exhibits anti-inflammatory activities. Small molecule inhibitor of a novel E3 or IκBα ubiquitin ligase distinct from SCFβTRCP (Skp1-cullin-F box conplex). Prevents IκBα degradation in cell culture (IC50 2.3 ± 0.09 μM). Blocks expression of NF-κB dependent cytokines: TNFα, IL-1β, and IL-6 in both cell culture (IC50 600-700 nM) and in vivo in animal models (NF-KB gene activation requires degradation of IKBα upon phosphorylation by IKK followed by ubiquitination).

Packaging

Light sensitive.

Certificate of Analysis

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Certificate of Origin

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