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T2307

Sigma-Aldrich

Tubulozole-T hydrochloride

≥98%

Synonym(s):
R 64181
Empirical Formula (Hill Notation):
C23H23Cl2N3O4S · HCl
CAS Number:
Molecular Weight:
544.88
MDL number:
PubChem Substance ID:

assay

≥98%

SMILES string

CCOC(=O)Nc1ccc(SC[C@@H]2CC[C@](C2)(Cn3ccnc3)c4ccc(Cl)cc4Cl)cc1

Biochem/physiol Actions

Anti-malarial agent; does not inhibit microtubule assemby; inactive trans-isomer of tubulozole-C

Certificate of Analysis

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More Documents

Quotes and Ordering

A Bell et al.
Parasitology research, 79(2), 146-152 (1993-01-01)
At low concentrations, both isomers of tubulozole (C, T) inhibit Plasmodium falciparum but only tubulozole C inhibits mammalian cells. Since tubulozole C prevents polymerization of mammalian tubulin whereas tubulozole T does not, the antimalarial action of tubulozoles may not involve
D Fong
FEMS microbiology letters, 107(1), 95-99 (1993-02-15)
For the cis and trans stereoisomers of the synthetic anti-microtubule compound tubulozole, at micromolar concentrations, tubulozole-C is cytotoxic to mammalian cells whereas tubulozole-T is not. The effect of tubulozoles on the parasitic protozoan Leishmania was tested. For the promastigote stage

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