Xylometazoline hydrochloride

2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride
Empirical Formula (Hill Notation):
C16H24N2 · HCl
CAS Number:
Molecular Weight:
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MDL number:
PubChem Substance ID:

Quality Level



SMILES string




InChI key


Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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5, 25 g in glass bottle

Biochem/physiol Actions

α-adrenoceptor agonist; imidazoline binding site ligand.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


Skull and crossbones

Signal Word


Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN 2811 6.1 / PGIII

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Görkem Eskiizmir et al.
European journal of clinical pharmacology, 67(1), 19-23 (2010-11-12)
Oxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects. The study population comprised thirty...
Britta Haenisch et al.
Fundamental & clinical pharmacology, 24(6), 729-739 (2009-12-25)
Oxymetazoline and xylometazoline are both used as nasal mucosa decongesting α-adrenoceptor agonists during a common cold. However, it is largely unknown which of the six α-adrenoceptor subtypes are actually present in human nasal mucosa, which are activated by the two...
Helle L Thulesius et al.
Rhinology, 49(1), 46-52 (2011-04-07)
Rhinomanometry before and after decongestion distinguishes a nasal airway organic stenosis from congestion of nasal mucosa in patients with nasal stuffiness. Together with rhinoscopy and patient history, it is used to decide if nasal surgery would benefit the patient. Rhinomanometry...
I T Bognar et al.
The Journal of pharmacology and experimental therapeutics, 254(2), 702-710 (1990-08-01)
Rat hearts were isolated with the vagus nerves intact and perfused, and the neuronal acetylcholine stores were pulse labeled with [14C]choline. The overflow of [14C]choline/acetylcholine evoked by extrinsic vagus nerve stimulation (3 Hz and 720 pulses or 10 Hz and...
Prasun Mishra et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 270(1), 117-121 (2012-03-20)
During nasal endoscopy it is essential to have proper visualization of structures with minimal discomfort to patient and surgeon. For this it is essential that the nose is well prepared before the procedure. The main objective of the study is...

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