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  • A0781
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A0781

Sigma-Aldrich

Aphidicolin from Nigrospora sphaerica

≥98% (HPLC), powder

Synonym(s):
APC
Empirical Formula (Hill Notation):
C20H34O4
CAS Number:
Molecular Weight:
338.48
Beilstein:
4689958
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

optical activity

[α]27/D +12°, c = 1 in methanol(lit.)

color

white

mp

227-233 °C (lit.)

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.)
DMSO: 10 mg/mL (stable at least six weeks at −20°C.)
methanol: 10 mg/mL
H2O: insoluble

antibiotic activity spectrum

neoplastics
viruses

Mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChI key

NOFOAYPPHIUXJR-APNQCZIXSA-N

Gene Information

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This Item
17827389458T8019
Aphidicolin Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.

Sigma-Aldrich

178273

Aphidicolin

Aphidicolin analytical standard

Supelco

89458

Aphidicolin

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

powder

form

solid

form

-

form

-

color

white

color

white

color

-

color

-

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.), DMSO: 10 mg/mL (stable at least six weeks at −20°C.), methanol: 10 mg/mL, H2O: insoluble

solubility

DMSO: 50 mg/mL, ethanol: soluble, methanol: soluble

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

300

Quality Level

100

Quality Level

100

Quality Level

200

Biochem/physiol Actions

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Caution

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

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