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A0781

Sigma-Aldrich

Aphidicolin from Nigrospora sphaerica

≥98% (HPLC), powder

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Synonym(s):
APC
Empirical Formula (Hill Notation):
C20H34O4
CAS Number:
38966-21-1
Molecular Weight:
338.48
Beilstein:
4689958
MDL number:
MFCD00083214
PubChem Substance ID:
57653817
NACRES:
NA.77

Quality Level

300

Assay

≥98% (HPLC)

form

powder

optical activity

[α]27/D +12°, c = 1 in methanol(lit.)

color

white

mp

227-233 °C (lit.)

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.)
DMSO: 10 mg/mL (stable at least six weeks at −20°C.)
methanol: 10 mg/mL
H2O: insoluble

antibiotic activity spectrum

neoplastics
viruses

Mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChI key

NOFOAYPPHIUXJR-APNQCZIXSA-N

Gene Information

human ... POLA1(5422) , POLD1(5424) , POLG(5428)

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This Item
SML0075SML0230C002
Aphidicolin from Nigrospora sphaerica ≥98% (HPLC), powder

Sigma-Aldrich

A0781

Aphidicolin from Nigrospora sphaerica

Sigma-Aldrich

Sigma-Aldrich

SML0075

OBAA

Sigma-Aldrich

Sigma-Aldrich

SML0230

GW-803430

(±)-Quinuclidinyl benzilate powder

Sigma-Aldrich

C002

(±)-Quinuclidinyl benzilate

form

powder

form

powder

form

powder

form

powder

color

white

color

white to tan

color

white to beige

color

white

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.), DMSO: 10 mg/mL (stable at least six weeks at −20°C.), methanol: 10 mg/mL, H2O: insoluble

solubility

DMSO: ≥5 mg/mL at 60 °C

solubility

DMSO: ≥4 mg/mL at warmed to 60 °C

solubility

chloroform: soluble (but decomposes within 24 hrs), methanol: stable (for up to two weeks at -20°C.)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

300

Quality Level

-

Quality Level

100

Quality Level

-

Biochem/physiol Actions

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Caution

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Comprehensive analysis of alterations in gene expression along with neoplastic transformation in human cells provides valuable information about the molecular mechanisms underlying transformation. To further address these questions, we performed whole transcriptome analysis to the human mesenchymal stem cell line
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PLoS pathogens, 11(8), e1005072-e1005072 (2015-08-22)
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