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A0835

N-Acetyl-Asp-Glu-Val-Asp-al

≥95%, powder

Synonym(s):

Ac-DEVD-CHO

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$178.00

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$613.00

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About This Item

Empirical Formula (Hill Notation):
C20H30N4O11
CAS Number:
169332-60-9
Molecular Weight:
502.47
NACRES:
NA.32
PubChem Substance ID:
24890193
UNSPSC Code:
12352209
MDL number:
MFCD00671412

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Product Name

N-Acetyl-Asp-Glu-Val-Asp-al, ≥95%, powder

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

SMILES string

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI key

UMBVAPCONCILTL-UHFFFAOYSA-N

biological source

synthetic

assay

≥95%

form

powder

color

white

solubility

H2O: 1 mg/mL

storage temp.

−20°C

Quality Level

100

Gene Information

human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)

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N-Acetyl-Asp-Glu-Val-Asp-al ≥95%, powder

Sigma-Aldrich

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N-Acetyl-Val-Glu-Ile-Asp-al ~99% (HPLC), powder

Sigma-Aldrich

A6339

N-Acetyl-Val-Glu-Ile-Asp-al

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide ≥97% (HPLC), powder

Sigma-Aldrich

A2559

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin ≥97% (HPLC), powder

Sigma-Aldrich

A1086

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin

assay

≥95%

assay

~99% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

biological source

synthetic

biological source

-

biological source

-

biological source

-

Gene Information

human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)

Gene Information

human ... CASP6(839)

Gene Information

human ... CASP3(836)

Gene Information

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

form

powder

form

powder

form

powder

form

powder

solubility

H2O: 1 mg/mL

solubility

H2O: 1 mg/mL

solubility

-

solubility

DMSO: 10 mM

Application

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples,[1] smooth muscle cells[2] and Jurkat T-cells.[3]

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.[4]
Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.[4]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ4792
BCCC7362
BCCB3851
BCBV6599
BCBR4557V

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Yu-Long Lan et al.
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