![[Arg13] Amyloid-β-Protein Fragment 1-40 ≥80% (HPLC), lyophilized powder](/deepweb/assets/sigmaaldrich/product/images/132/249/f6ab5ff8-bec9-4c18-b8b8-7b6bc8f9d58e/640/f6ab5ff8-bec9-4c18-b8b8-7b6bc8f9d58e.jpg)
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A1075
Amyloid β Protein Fragment 1-40
≥90% (HPLC), powder
Synonym(s):
Aβ40
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0.1 MG
$216.00
0.5 MG
$671.94
About This Item
Empirical Formula (Hill Notation):
C194H295N53O58S
CAS Number:
Molecular Weight:
4329.80
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
Quality Level
assay
≥90% (HPLC)
form
powder
color
white
solubility
1% acetic acid: 1 mg/mL
saline: insoluble
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... APP(351)
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1 of 4
This Item | A4559 | A2201 | AG968 |
|---|---|---|---|
| assay ≥90% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay >97.0% |
| form powder | form powder | form powder | form powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. - |
| solubility 1% acetic acid: 1 mg/mL, saline: insoluble | solubility - | solubility - | solubility - |
Amino Acid Sequence
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
General description
Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3.[1] Aβ40 is predominantly present in the vascular amyloid deposits.[2] Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.[3]
Application
Amyloid β Protein Fragment 1-40 has been used:
- in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies[4]
- as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma[5]
- as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts[6]
Biochem/physiol Actions
Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels.[7]
Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.
Reconstitution
For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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