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A111040

Sigma-Aldrich

DMT-dA(bz) Phosphoramidite

configured for MerMade

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Synonym(s):
DMT-dA(bz) Amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyadenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
Empirical Formula (Hill Notation):
C47H52N7O7P
CAS Number:
Molecular Weight:
857.93
MDL number:
PubChem Substance ID:
NACRES:
NA.51

biological source

non-animal source (no BSE/TSE risk)

Quality Level

type

for DNA synthesis

product line

Proligo Reagents

Assay

≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)

form

powder or granules

technique(s)

oligo synthesis: suitable

impurities

≤0.3 wt. % water content (Karl Fischer)

color

white to off-white

λ

conforms (UV/VIS Identity)

compatibility

configured for MerMade

nucleoside profile

base: deoxyadenosine
base protecting group: benzoyl
2' protecting group: none
5' protecting group: DMT
deprotection: standard

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7

InChI

1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1

InChI key

GGDNKEQZFSTIMJ-AKWFTNRHSA-N

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This Item
A111080A111050A111060
assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

form

powder or granules

form

powder or granules

form

powder or granules

form

powder or granules

impurities

≤0.3 wt. % water content (Karl Fischer)

impurities

≤0.3 wt. % water content (Karl Fischer)

impurities

≤0.3 wt. % water content (Karl Fischer)

impurities

≤0.3 wt. % water content (Karl Fischer)

color

white to off-white

color

white to off-white

color

white to off-white

color

white to off-white

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. Exocyclic amine functions are protected by a benzoyl group (dA(bz) and dC(bz)) or isobutyryl group (dG(ib))Key features of DNA phosphoramidites:
  • Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
  • The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides
The product belongs to MerMade synthesizers.

Packaging

A111040-1G packaged in a 1 oz bottle with a 28-400 cap
A111040-10G packaged in a 8 oz bottle with a 28-400 cap
A111040-6x5G packaged in a 8 oz bottle with a 28-400 cap
A111040-6x10G packaged in a 8 oz bottle with a 28-400 cap
A111040-20x10G packaged in a 1 L bottle with GL 45

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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