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A1346

ASB-14

Synonym(s):

3-[N,N-Dimethyl(3-myristoylaminopropyl)ammonio]propanesulfonate, Amidosulfobetaine-14

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About This Item

Empirical Formula (Hill Notation):
C22H46N2O4S
CAS Number:
216667-08-2
Molecular Weight:
434.68
UNSPSC Code:
12161902
NACRES:
NA.28
MDL number:
MFCD03456122

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SMILES string

[S](=O)(=O)([O-])CCC[N+](CCCNC(=O)CCCCCCCCCCCCC)(C)C

InChI

1S/C22H46N2O4S/c1-4-5-6-7-8-9-10-11-12-13-14-17-22(25)23-18-15-19-24(2,3)20-16-21-29(26,27)28/h4-21H2,1-3H3,(H-,23,25,26,27,28)

InChI key

UTSXERRKRAEDOV-UHFFFAOYSA-N

description

zwitterionic

assay

≥95.0% (HPLC)

form

powder

mol wt

average mol wt >10,000

aggregation number

≥23

storage temp.

2-8°C

Quality Level

200

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This Item
182750SAB1403263SAB1407509
ASB-14

Sigma-Aldrich

A1346

ASB-14

ASB-14 A zwitterionic amidosulfobetaine detergent useful for solubilizing proteins visualized by 2D-electrophoresis.

Millipore

182750

ASB-14

Monoclonal Anti-ASB4 antibody produced in mouse clone 2G11, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1403263

Monoclonal Anti-ASB4 antibody produced in mouse

Anti-ASB4 antibody produced in mouse purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1407509

Anti-ASB4 antibody produced in mouse

assay

≥95.0% (HPLC)

assay

≥97% (HPLC)

assay

-

assay

-

form

powder

form

solid

form

buffered aqueous solution

form

buffered aqueous solution

aggregation number

≥23

aggregation number

-

aggregation number

-

aggregation number

-

storage temp.

2-8°C

storage temp.

10-30°C

storage temp.

−20°C

storage temp.

−20°C

mol wt

average mol wt >10,000

mol wt

-

mol wt

antigen ~38.1 kDa

mol wt

antigen ~38.9 kDa

description

zwitterionic

description

-

description

-

description

-

General description

ASB-14 comprises alkyl tails and amidosulfobetaine headgroup.[1]

Application

ASB-14 has been used as a component of rehydration buffer for proteomic sample preparation from Leishmania donovani.[2]
Zwitterionic detergent. Useful for solubilization of proteins, including membrane proteins, for 2D electrophoresis.

Biochem/physiol Actions

ASB-14 is useful in proteasome extraction especially for the membrane associated proteins.[3] Along with CHAPS (3-(3-cholamidopropyl)dimethylammonio)-1-propanesulfonate), it is employed in protein solubilization even in the presence of thiourea.[4]

Analysis Note

ASB-14 (amidosulfobetaine-14), a membrane solubilizing zwitterionic detergent (medium chain amidosulfobetaine surfactant), may be used in protein and macromolecule research for the preparative extraction and solubilization of proteins for separation and analysis by methods such as 2D-electrophoresis. ASB-14 may be used in tissue engineering for antigen removal (AR) for xenogeneic scaffold generation. ASB-14 may be used to develop and study zwitterionic micelles.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000484431
0000484431
0000382414
0000382414
SLCN7658

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Nityakalyani Srinivas et al.
Science (New York, N.Y.), 327(5968), 1010-1013 (2010-02-20)
Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a
Thermodynamic and structural characterization of zwitterionic micelles of the membrane protein solubilizing amidosulfobetaine surfactants ASB-14 and ASB-16
D Andrea MG, et al.
Langmuir, 27(13), 8248-8256 (2011)
Francisella t ularensis Proteome: Low Levels of ASB-14 Facilitate the Visualization of Membrane Proteins in Total Protein Extracts
Twine SM, et al.
Journal of Proteome Research, 4(5), 1848-1854 (2005)
Zhiquan Chen et al.
Free radical biology & medicine, 102, 77-86 (2016-11-15)
Nrf2/ARE signaling pathway is a crucial cellular defense system to cope with oxidative stress, which is adaptively activated, in diabetic condition that is not efficient enough to resist the oxidative stress provoked by hyperglycemia. We have previously demonstrated that Connexin43
Daniel Martins-de-Souza et al.
Briefings in functional genomics & proteomics, 6(1), 70-75 (2007-06-09)
Protein extraction is the most important step to reveal a proteome by Two-Dimensional Gel Electrophoresis. Usually, the urea/thiourea based standard protein extraction buffer (SB) is combined with detergents with the aim of achieving better resolution and solubilization of different classes
View All Related Papers

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