All Photos(7)

A1887

Sigma-Aldrich

Albumin from human serum

lyophilized powder, essentially fatty acid free

Synonym(s):
HSA
CAS Number:
EC Number:
MDL number:
eCl@ss:
42010201

Quality Level

biological source

human

assay

≥96% (agarose gel electrophoresis)

form

lyophilized powder

mol wt

monomer calculated mol wt 66478 Da

application(s)

ELISA: suitable
tissue culture: suitable
western blot: suitable

impurities

HIV I and HIVII, HCV and HBsAg, tested negative
≤0.007% Fatty Acids

solubility

H2O: soluble 50 mg/mL, clear to slightly hazy

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... ALB(213)

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General description

Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.

Application

Albumin from human serum has been used:
  • as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins
  • to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin
  • to study its effect on wound healing process

Packaging

100, 500 mg in poly bottle
1, 5, 10, 25 g in poly bottle

Biochem/physiol Actions

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.
Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.

Preparation Note

Prepared from albumin (A1653)

Other Notes

View more information on human serum albumin.

Storage Class Code

12 - Non Combustible Liquids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

A J Crowle et al.
Infection and immunity, 55(12), 2945-2950 (1987-12-01)
Historically, sunlight has seemed to fortify antituberculosis resistance. Evidence is presented here suggesting a role for vitamin D in this effect. The active metabolite of this photosynthesized vitamin, 1,25-dihydroxy-vitamin D3 (1,25D), promotes maturation and activation of human monocytes and macrophages...
Ferenc Zsila
The journal of physical chemistry. B, 117(37), 10798-10806 (2013-09-06)
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein. It can be inferred from the spectroscopic...
S Miyata et al.
The Journal of clinical investigation, 89(4), 1102-1112 (1992-04-01)
Pyrraline is one of the major Maillard compounds resulting from the reaction of glucose with amino compounds at slightly acidic pH. For in vivo studies, monoclonal pyrraline antibodies were raised after immunization of Balb/c mice with keyhole limpet hemocyamin-caproyl pyrraline...
Serum albumin and body weight as predictors of postoperative course in colorectal cancer
Hickman DM, et al.
Journal of Parenteral and Enteral Nutrition, 4(3), 314-316 (1980)
J Barré et al.
Clinical chemistry, 31(1), 60-64 (1985-01-01)
Equilibrium dialysis, ultrafiltration, and ultracentrifugation were compared to determine their reliability and applicability in the study of binding of an anticonvulsant drug, valproic acid, by plasma proteins. We studied drug binding with pooled serum and with solutions of human serum...

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