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MilliporeSigma

A1895

Sigma-Aldrich

Aurintricarboxylic acid

≥85% purity (titration), practical grade, powder

Synonym(s):

ATA

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25 G
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About This Item

Empirical Formula (Hill Notation):
C22H14O9
CAS Number:
Molecular Weight:
422.34
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

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$68.35

List Price$72.10Save 5%
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In StockDetails


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Product Name

Aurintricarboxylic acid, practical grade, ≥85% (titration), powder

grade

practical grade

Quality Level

assay

≥85% (titration)

form

powder

technique(s)

titration: suitable

color

red to very dark red, and Red-Brown andBrown-Red

mp

300 °C (lit.)

solubility

1 M NH4OH: 10 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O

InChI

1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)

InChI key

GIXWDMTZECRIJT-UHFFFAOYSA-N

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This Item
A0885A36883189400
technique(s)

titration: suitable

technique(s)

-

technique(s)

titration: suitable

technique(s)

-

grade

practical grade

grade

-

grade

ACS reagent

grade

-

color

red to very dark red, and Red-Brown andBrown-Red

color

dark red

color

dark red

color

red

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

-

form

powder

form

powder

form

powder or crystals

form

solid

solubility

1 M NH4OH: 10 mg/mL

solubility

water: soluble 100 mg/mL, dark red

solubility

water: soluble 100 mg/mL

solubility

0.1 M NaOH: 35 mg/mL

Application

  • Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum.[1]
  • It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase).[2]
  • It has been used as a ribonuclease inhibitor.[3]

Biochem/physiol Actions

Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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