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A2169

Sigma-Aldrich

3′-Azido-3′-deoxythymidine

≥98% (HPLC), powder, reverse transcriptase inhibitor

Synonym(s):

AZT, Azidothymidine, ZDV, Zidovudine

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25 MG
$88.35
100 MG
$289.75
250 MG
$534.00
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$1,710.00

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25 MG
$88.35
100 MG
$289.75
250 MG
$534.00
1 G
$1,710.00

About This Item

Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
30516-87-1
Molecular Weight:
267.24
Beilstein/REAXYS Number:
3595791
MDL number:
MFCD00006536
UNSPSC Code:
12352200
PubChem Substance ID:
24278143
NACRES:
NA.77

$88.35

List Price$93.00Save 5%
Web-Only Promotion

In StockDetails

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Product Name

3′-Azido-3′-deoxythymidine, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

mp

113-115 °C (lit.)

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

Gene Information

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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Show Differences

1 of 4

This Item
BP8031724500Y0002266
3′-Azido-3′-deoxythymidine ≥98% (HPLC)

A2169

3′-Azido-3′-deoxythymidine

Zidovudine British Pharmacopoeia (BP) Reference Standard

BP803

Zidovudine

Zidovudine United States Pharmacopeia (USP) Reference Standard

1724500

Zidovudine

Zidovudine for system suitability A CRS, European Pharmacopoeia (EP) Reference Standard

Y0002266

Zidovudine for system suitability A

form

powder

form

solid

form

-

form

-

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 50 mg/mL

solubility

-

solubility

-

solubility

-

mp

113-115 °C (lit.)

mp

113-115 °C (lit.)

mp

113-115 °C (lit.)

mp

113-115 °C (lit.)

Application

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration[1] and as an antimicrobial agent to evaluate its anti-Salmonella activity.[2]

Biochem/physiol Actions

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.
Reverse transcriptase inhibitor active against HIV-1 virus.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW0371
MKCW5948
MKCS1355
MKCR8766
MKCQ4508

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Questions

  1. For the use of this product in cell culture, what would be the best conditions for making stock solutions. Solvent, concentration, filtering, storage temp etc.?

    1 answer

    1. Unfortunately, this product has not been tested for cell culture applications. This compound is soluble at 50 mg/mL in water. For use in cell culture, the stock solution should be filter sterilized. Syringe filter product SLGVR33RS may be of interest. The pharmaceutical literature suggests that the stock solution is stable for 1 day at room temperature and 2 days if refrigerated.

      See the link below to a publication (page 3) regarding the stability of AZT in solution:
      https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019910s041lbl.pdf

      Helpful?

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