A2327
Adrenomedullin 52 human
≥90% (HPLC), powder
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 0.1 mg | Available to ship TODAYfromMILWAUKEE | $666.00 |
About This Item
Empirical Formula (Hill Notation):
C264H406N80O77S3
CAS Number:
Molecular Weight:
6028.73
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
General description
Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia.
Application
Adrenomedullin 52 human has been used in tube formation assay in human umbilical vein endothelial cells (HUVECs).
Biochem/physiol Actions
Elicits a potent hypotensive effect; plays a key role in regulating endometrial angiogenesis.
Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form lyophilized powder |
| assay ≥90% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (SDS-PAGE) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... ADM(133) | Gene Information human ... ADM(133) | Gene Information human ... EDN2(1907) | Gene Information - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Adrenomedullin in the growth modulation and differentiation of acute myeloid leukemia cells.
Di Liddo R, et al.
International Journal of Oncology, 48(4), 1659-1669 (2016)
Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3.
Robinson, SD et al.
Journal of Pharmacology and Experimental Therapeutics, 331(2), 513-521 (2009)
Transcriptional regulation of adrenomedullin by oncostatin M in human astroglioma cells: Implications for tumor invasion and migration.
Lim SY, et al.
Scientific Reports, 4(4), 6444-6444 (2014)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2327-.1MG | 04061833350003 |