This IC50 for this compound has not been determined. A brief search of the literature shows a fairly broad range in various organisms and/or tissue types. A more thorough literature search would be advised.
A3085
5-(N-Ethyl-N-isopropyl)amiloride
≥98% (TLC), powder, Na⁺/H⁺ antiport inhibitor
Synonym(s):
EIPA
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 mg | Estimated to ship TODAYfromMILWAUKEE | $258.00 | |
| 100 mg | Estimated to ship TODAYfromMILWAUKEE | $852.00 |
About This Item
Empirical Formula (Hill Notation):
C11H18ClN7O
CAS Number:
Molecular Weight:
299.76
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
5-(N-Ethyl-N-isopropyl)amiloride,
biological source
synthetic
Quality Level
assay
≥98% (TLC)
form
powder
mp
202-205 °C (lit.)
solubility
methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
storage temp.
2-8°C
SMILES string
CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
InChI
1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChI key
QDERNBXNXJCIQK-UHFFFAOYSA-N
Gene Information
human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)
Application
5-(N-Ethyl-N-isopropyl)amiloride has been used:
- as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
- in Pluronic F-127 stock solution for Drosophila larval live-imaging
- in choline chloride solution as an experimental perfusate, to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo
Biochem/physiol Actions
Selective blocker of Na+/H+ antiport
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (TLC) | assay ≥98% (TLC) | assay ≥98% | assay ≥98% (TLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
| solubility methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow | solubility methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow | solubility DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow | solubility chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow |
| mp 202-205 °C (lit.) | mp 200-201 °C | mp 278 °C | mp - |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Zhao Luo et al.
Journal of peptide science : an official publication of the European Peptide Society, 22(11-12), 689-699 (2016-10-16)
Cell-penetrating peptides (CPPs) have been shown to be potential drug carriers for cancer therapy. The inherently low immunogenicity and cytotoxicity of human-derived CPPs make them more suitable for intracellular drug delivery compared to other delivery vehicles. In this work, the
Na+/H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals
Rossano AJ, et al.
The Journal of Physiology, 595(3), 805-824 (2017)
Rachael L Hardison et al.
mSphere, 3(5) (2018-09-14)
Nutrient limitation restricts bacterial growth in privileged sites such as the middle ear. Transient heme-iron restriction of nontypeable Haemophilus influenzae (NTHI), the major causative agent of chronic and recurrent otitis media (OM), promotes new and diverse phenotypes that can influence
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A3085-25MG | 04061833360286 |
| A3085-100MG | 04061832569055 |
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¿Cuál es el IC50 de esta sustancia?
1 answer-
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How can I store a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
1 answer-
We do not have solution stability information for 5-(N-Ethyl-N-isopropyl)amiloride. The product is sensitive to light, particularly in solution. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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What can I use to make a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
1 answer-
We test solubility of 5-(N-Ethyl-N-isopropyl)amiloride in methanol (10 mg/mL), yielding a clear yellow solution. It is also soluble in DMSO, and in dilute aqueous acid. It is insoluble in water.
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What concentration of Product A3085, 5-(N-Ethyl-N-isopropyl)amiloride, should I use in my experiment?
1 answer-
We have the following references for the use of 5-(N-Ethyl-N-isopropyl)amiloride. A review article mentions the use of EIPA at 1 micromolar to probe Na+ channels in rat alveolar epithelial cells; see: Matalon, S., et al., Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells. Am. J. Physiol., 271, L1-L22 (1996). A study of the effects of EIPA on infarction in isolated rabbit hearts and cardiomyocytes has been reported; see: Sato, H., et al., The mechanism of protection from 5 (N-ethyl-N-isopropyl)amiloride differs from that of ischemic preconditioning in rabbit heart. Basic Res. Cardiol., 92, 339-350 (1997).
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