A3355

Sigma-Aldrich

ATC0175

≥98% (HPLC), solid

Synonym(s):
N-(cis-4-{[4-(Dimethylamino)quinazolin-2-yl]amino}cyclohexyl)-3,4-difluorobenzamide HCl
Empirical Formula (Hill Notation):
C23H26ClF2N5O
CAS Number:
Molecular Weight:
461.94
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 5 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)c1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)c3ccc(F)c(F)c3)nc4ccccc14

InChI

1S/C23H25F2N5O.ClH/c1-30(2)21-17-5-3-4-6-20(17)28-23(29-21)27-16-10-8-15(9-11-16)26-22(31)14-7-12-18(24)19(25)13-14;/h3-7,12-13,15-16H,8-11H2,1-2H3,(H,26,31)(H,27,28,29);1H/t15-,16+;

InChI key

HUUPKFUYSQNNLO-FAESNJTISA-N

Packaging

10 mg in glass bottle

Biochem/physiol Actions

Non-peptide, orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist.
ATC0175 is a non-peptide, orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Shigeyuki Chaki et al.
The Journal of pharmacology and experimental therapeutics, 313(2), 831-839 (2005-01-29)
Melanin-concentrating hormone (MCH) is a cyclic peptide produced in the lateral hypothalamus. It has been implicated in a number of physiological processes including feeding behavior, energy balance, and the regulation of emotional states. Here, we report in vitro and in...

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