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A3886

Sigma-Aldrich

Aprotinin from bovine lung

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Synonym(s):
BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)
Empirical Formula (Hill Notation):
C284H432N84O79S7
CAS Number:
Molecular Weight:
6511.44
EC Number:
MDL number:

biological source

bovine lung

Quality Level

form

powder

mol wt

~6,500

packaging

vial of 15 mg

solubility

glycerol: 3 mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)

UniProt accession no.

storage temp.

−20°C

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

Gene Information

cow ... PTI(404172)

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This Item
A4529A3428SRE0078
Aprotinin from bovine lung

A3886

Aprotinin from bovine lung

Aprotinin from bovine lung lyophilized powder, 3-7 TIU/mg solid

A4529

Aprotinin from bovine lung

Aprotinin from bovine lung lyophilized powder, 3-8 TIU/mg solid, BioReagent, suitable for cell culture

A3428

Aprotinin from bovine lung

Aprotinin from bovine lung lyophilized powder, ≥3 TIU/mg solid, Suitable for manufacturing of diagnostic kits and reagents

SRE0078

Aprotinin from bovine lung

Gene Information

cow ... PTI(404172)

Gene Information

cow ... PTI(404172)

Gene Information

cow ... PTI(404172)

Gene Information

-

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

400

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

glycerol: 3 mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)

solubility

H2O: >10 mg/mL

solubility

H2O: 5 mg/mL

solubility

-

Application

Aprotinin is largely used as an inhibitor of trypsin.
Gel filtration molecular weight marker

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Unit Definition

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Safety of aprotinin in adult cardiac surgery: revisiting the validity of a mixed-treatment comparison meta-analysis.
Ferrán Catalá-López
The Journal of thoracic and cardiovascular surgery, 145(2), 610-610 (2013-01-17)
III. Aprotinin and cardiac surgery: a sorry tale of evidence misused.
V McMullan et al.
British journal of anaesthesia, 110(5), 675-678 (2013-04-20)
EMA, transparency, and decision-making process.
Måns Rosén
Lancet (London, England), 382(9886), 26-27 (2013-07-09)

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