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A4034

Sigma-Aldrich

(+)-Sodium L-ascorbate

powder, BioReagent, suitable for cell culture

Synonym(s):
L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt
Empirical Formula (Hill Notation):
C6H7NaO6
CAS Number:
Molecular Weight:
198.11
Beilstein:
3767246
EC Number:
MDL number:
eCl@ss:
34058010
PubChem Substance ID:
NACRES:
NA.75

biological source

synthetic (organic)

Quality Level

product line

BioReagent

Assay

≥98%

form

powder

mol wt

Mw 135.13 g/mol

technique(s)

cell culture | mammalian: suitable
cell culture | plant: suitable

color

white to off-white

mp

220 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

SMILES string

[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

InChI

1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1

InChI key

PPASLZSBLFJQEF-RXSVEWSESA-M

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This Item
11140Y0000039PHR1279
(+)-Sodium L-ascorbate powder, BioReagent, suitable for cell culture

Sigma-Aldrich

A4034

(+)-Sodium L-ascorbate

(+)-Sodium L-ascorbate BioXtra, ≥99.0% (NT)

Sigma-Aldrich

11140

(+)-Sodium L-ascorbate

Sodium ascorbate European Pharmacopoeia (EP) Reference Standard

Y0000039

Sodium ascorbate

Sodium ascorbate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1279

Sodium ascorbate

assay

≥98%

assay

≥99.0% (NT)

assay

-

assay

-

form

powder

form

powder or crystals

form

solid

form

-

technique(s)

cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

-

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white to off-white

color

white

color

-

color

-

mp

220 °C (dec.) (lit.)

mp

220 °C (dec.) (lit.)

mp

220 °C (dec.) (lit.)

mp

220 °C (dec.) (lit.)

General description

(+)-Sodium L-ascorbate (SA) is a potential antioxidant and is a derivative of vitamin C (L-ascorbic acid). It is widely used as a food additive. In addition, SA enhances growth retardation activity of bleomycin sulfate, R020-1724 (an inhibitor of cyclic nucleotide phosphodiesterase), prostaglandin E1 and sodium butyrate agents on neuroblastoma cells in culture. Elevated levels of SA induces two-stage urinary bladder carcinogenesis in rats. sodium L-ascorbate in combination with collagenogenesis inhibitors is used to treat dermal scars and keloids.

Application

(+)-Sodium L-ascorbate has been used:
  • to produce H2O2 in cell culture media
  • as a reducing agent for a cell-permeable artificial electron donor, N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD)
  • to study its effect on production of collagen and elastic fibers in fibroblasts cultures derived from normal human skin and dermal fat

Used for preparation of plant extracts; reductant for the isolation of chloroplasts.

Biochem/physiol Actions

Antioxidant

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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25G
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Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture
Prasad KN, et al.
Proceedings of the National Academy of Sciences of the USA, 76(2), 829-832 (1979)
Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats
Fukushima S, et al.
Cancer Research, 43(9), 4454-4457 (1983)
Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media
Long LH and Halliwell B
Biochemical and Biophysical Research Communications, 388(4), 700-704 (2009)
Artefacts in cell culture: alpha-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media
Long LH and Halliwell B
Biochemical and Biophysical Research Communications, 406(1), 20-24 (2011)
The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
Bordt EA, et al.
Developmental Cell, 40(6), 583-594 (2017)

Articles

Ascorbate in Cell Culture

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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