Bovine Serum Albumin

lyophilized powder, 1× crystallized, ≥97% (agarose gel electrophoresis)

Albumin bovine serum, Bovine albumin, BSA
CAS Number:
EC Number:
MDL number:

Quality Level

biological source



≥97% (agarose gel electrophoresis)


lyophilized powder



mol wt

~66 kDa

purified by

cold ethanol fractionation


poly bottle of


USA origin


ELISA: suitable




water: soluble (50 mg/ml)

UniProt accession no.

storage temp.


Gene Information

bovine ... ALB(280717)

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General description

Albumin is the most abundant plasma protein in humans. High levels of albumin are associated with dehydration. Albumin turnover is seen in infants with iron deficiency anemia. Serum albumin is a reliable prognostic indicator for liver disease. Oxidative damage of albumin is associated with advanced liver disease.


Bovine Serum Albumin has been:
  • as an additive in washout solution and fluorescent dye solution
  • as a supplement in Waymouth medium and modified essential medium-α (MEMα )
  • in plant extract for the protein precipitation test
  • as a component in Ringer′s solution to rinse the retinal tissue


1, 5, 10, 25, 100 g in poly bottle

Biochem/physiol Actions

Certain conformational and primary-sequence epitopes of BSA are suspected allergens in human beef and milk allergies.

Preparation Note

Often referred to as Cohn fraction V; this product is prepared by a modified method of the Cohn cold ethanol fractionation method. Further purified by a proprietary crystallization method
Serum albumin may be referred to as Fraction V. This naming convention is taken from the original Cohn method of fractionating serum proteins using cold ethanol precipitation. Serum albumin was found in the fifth ethanol fraction using Cohn′s method. Since then, the term "Fraction V" has been used by some to describe serum albumin regardless of the method of preparation. Others have used this term to describe serum albumin purified by ethanol fractionation methods that have been highly modified since the original Cohn method was described. Sigma-Aldrich manufactures and distributes serum albumins purified from a variety of primary methods including the true Cohn fractionation method, modified ethanol fractionation methods, heat shock and chromatography. Additional purification steps may include crystallization or charcoal filtration.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Effects of condensed tannins prepared from leaves of fodder plants on digestive enzymes in vitro and in the intestine of rats
Horigome T, et al.
British Journal of Urology, 60(2), 275-285 (1988)
A revised protocol for in vitro development of mouse oocytes from primordial follicles dramatically improves their developmental competence
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Distribution of potassium conductance in mammalian Muller (glial) cells: a comparative study
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The Journal of Neuroscience, 7(8), 2423-2432 (1987)
Bingmei M Fu et al.
Microvascular research, 68(1), 51-62 (2004-06-29)
To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently...
Meghan Riddell et al.
Nature communications, 9(1), 5357-5357 (2018-12-19)
Strict regulation of proliferation is vital for development, whereas unregulated cell proliferation is a fundamental characteristic of cancer. The polarity protein atypical protein kinase C lambda/iota (aPKCλ) is associated with cell proliferation through unknown mechanisms. In endothelial cells, suppression of...

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