All Photos(3)

A5285

Sigma-Aldrich

Adenosine 5′-diphosphate monopotassium salt dihydrate

bacterial, ≥95%, powder

Synonym(s):
ADP
Empirical Formula (Hill Notation):
C10H14KN5O10P2 · 2H2O
CAS Number:
Molecular Weight:
501.32
MDL number:
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.77

Quality Level

biological source

bacterial

assay

≥95%

form

powder

storage temp.

−20°C

SMILES string

[O-]P(OP(OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N2C3=C(N=C2)C(N)=NC=N3)(O)=O)(O)=O.[K+]

InChI

1S/C10H15N5O10P2.K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1

InChI key

ZNCWUOPIJTUALR-MCDZGGTQSA-M

Gene Information

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Application

Adenosine 5′-diphosphate is a P2Y receptor agonist. Adenosine 5′-diphosphate has been used to study the release, neuronal effects and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain. Adenosine 5′-diphosphate has also been used to compare prasugrel versus clopidogrel antiplatelet therapy after acute coronary syndrome.

Packaging

100 mg in poly bottle
1 g in poly bottle

Biochem/physiol Actions

P2Y receptor agonist.

Storage Class Code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Daniel S Ziemianowicz et al.
Journal of the American Society for Mass Spectrometry, 31(2), 207-216 (2020-02-08)
The functional properties of a protein are strongly influenced by its topography, or the solvent-facing contour map of its surface. Together with crosslinking, covalent labeling mass spectrometry (CL-MS) has the potential to contribute topographical data through the measurement of surface...
Leonie Durnin et al.
The European journal of neuroscience, 35(3), 423-435 (2012-01-27)
Recent evidence supports an emerging role of β-nicotinamide adenine dinucleotide (β-NAD(+) ) as a novel neurotransmitter and neuromodulator in the peripheral nervous system -β-NAD(+) is released in nerve-smooth muscle preparations and adrenal chromaffin cells in a manner characteristic of a...
James E Tcheng et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 12(2), 83-91 (2012-02-10)
Antithrombotic therapy is imperative in the management of patients presenting with an acute coronary syndrome (ACS). The combination of antiplatelet therapy in conjunction with antithrombotic therapy has become the standard of care in improving the morbidity and mortality of patients...
Meera Kumar et al.
SLAS discovery : advancing life sciences R & D, 25(3), 320-326 (2019-12-24)
Production of adenosine in the extracellular tumor microenvironment elicits strong immunosuppression and is associated with tumor progression. Thus, targeting adenosine-generating ectonucleotidases is a potential strategy to stimulate and prolong antitumor immunity. Because the reaction products of ectonucleotidases differ by a...
Theresa H Tam et al.
The Journal of biological chemistry, 295(15), 4902-4911 (2020-03-07)
Obesity and elevation of circulating free fatty acids are associated with an accumulation and proinflammatory polarization of macrophages within metabolically active tissues, such as adipose tissue, muscle, liver, and pancreas. Beyond macrophages, neutrophils also accumulate in adipose and muscle tissues...

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