A5285

Adenosine 5′-diphosphate monopotassium salt dihydrate

bacterial, ≥95%, powder

• Synonym(s): Adenosine 5′-Diphosphate Potassium Salt, ADP
• Empirical Formula (Hill Notation): C₁₀H₁₄KN₅O₁₀P₂ · 2H₂O
• CAS Number: 72696-48-1
• Molecular Weight: 501.32
• MDL number: MFCD00066472
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24890964
• NACRES: NA.77

Properties

• biological source: bacterial
• Quality Level: 200
• assay: ≥95%
• form: powder
• storage temp.: −20°C
• SMILES string: [O-]P(OP(OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N2C3=C(N=C2)C(N)=NC=N3)(O)=O)(O)=O.[K+]
• InChI: 1S/C10H15N5O10P2.K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
• InChI key: ZNCWUOPIJTUALR-MCDZGGTQSA-M
• Gene Information: human ... HSP90AA1(3320), P2RY1(5028)

Description

General description

Adenosine diphosphate (ADP) is a crucial component for energy flow in living organisms. Its structure consists of a sugar backbone connected to adenine and two phosphate groups attached to the fifth carbon atom of the ribose sugar. ADP serves a precursor for ATP biosynthesis.[1] ADP acts as a weak platelet agonist, specifically targeting the P2Y receptor. However, ADP plays a vital role in platelet function by enhancing the effects of other platelet agonists and promoting the stability of platelet aggregates when released from platelet dense granules.[2]

Application

Adenosine 5′-diphosphate has been used to study the release, neuronal effects, and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD⁺) in the rat brain. Adenosine 5′-diphosphate has also been used to compare prasugrel versus clopidogrel antiplatelet therapy after acute coronary syndrome.

Adenosine 5′-diphosphate monopotassium salt dihydrate (ADP) has been used:

• in titration to determine complex I-supported respiration in permeabilized muscle fibers[3]
• in titrations to determine ADP-stimulated respiratory kinetics[4]
• in the preparation of ADP solution for measuring mitochondrial respiration[5]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)