A5783

Sigma-Aldrich

Albumin, lactosyl bovine

lyophilized powder

Synonym(s):
Albumin-N-1-(deoxylactitol)
MDL number:

form

lyophilized powder

Quality Level

composition

Protein, ~85% biuret

extent of labeling

10-20 mol disaccharide per mol albumin

solubility

H2O: soluble 50 mg/mL

storage temp.

−20°C

General description

The most abundant plasma protein in mammals is albumin. It is produced in the liver and transferred as a non-glycosylated protein into the plasma. This multifunctional protein has an amazing ability to bind to ligands.

Application

Bovine serum albumin (BSA) is extensively used for drug delivery since it is widely available, cheap and easily purified, has ligand-binding properties, and is widely accepted in the pharmaceutical industry.
Albumin was used in a study to test the transfer mechanism of regulated blood-cerebrospinal fluid in immature rats.

Biochem/physiol Actions

Albumin is the most important circulatory protein involved in the control of Ca2+ (and Mg2+) levels in mammals.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing citrate buffer salts

Preparation Note

Prepared from albumin (A 7638) and α-lactose coupled via reductive amination.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

M D Habgood et al.
The Journal of physiology, 456, 181-192 (1992-10-01)
1. The transfer of albumin between the blood and the cerebrospinal fluid (CSF) has been investigated in neonatal (3 days old) and juvenile (20 days old) rats. At both stages of postnatal development, all of the albumin present in the...
Proteins containing reductively aminated disaccharides. Synthesis and chemical characterization.
B A Schwartz et al.
Archives of biochemistry and biophysics, 181(2), 542-549 (1977-06-01)
Yuangang Zu et al.
International journal of nanomedicine, 8, 1207-1222 (2013-04-10)
The livertaxis of glycyrrhizic acid-conjugated bovine serum albumin (GL-BSA) has been reported in the literature. Now, in this paper, we describe a novel type of drug-targeted delivery system containing 10-hydroxycamptothecin (HCPT) with liver tumor targeting. First, GL was coupled to...
Karolina A Majorek et al.
Molecular immunology, 52(3-4), 174-182 (2012-06-09)
Serum albumin (SA) is the most abundant plasma protein in mammals. SA is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules. Due to...

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