A5843

Albumin from human serum

lyophilized powder, low endotoxin

• Synonym(s): HSA
• CAS Number: 70024-90-7
• UNSPSC Code: 12352202
• eCl@ss: 42010201
• EC Number: 274-272-6
• NACRES: NA.25
• MDL number: MFCD00081418
• Biological source: human
• Assay: ≥96% (agarose gel electrophoresis)
• Form: lyophilized powder
• Technique(s): activity assay: suitable
• Impurities: HIV I and HIVII, HCV and HBsAg, tested negative, ≤1.0 EU/mg endotoxin

Properties

• biological source: human
• Quality Level: 200
• assay: ≥96% (agarose gel electrophoresis)
• form: lyophilized powder
• mol wt: monomer calculated mol wt 66478 Da
• technique(s): activity assay: suitable
• impurities: HIV I and HIVII, HCV and HBsAg, tested negative, ≤1.0 EU/mg endotoxin
• solubility: H₂O: soluble 50 mg/mL
• UniProt accession no.: P02768
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)C(F)(F)C(F)(F)F
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213)

Description

General description

Albumin is the most copious protein in blood plasma. Liver produces human albumin. [1]

Application

Albumin was used to test its effect on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumonia.[2] It has been clinically used in serious and often life-threatening conditions, such as shock and blood loss due to trauma, burns, and surgery.[1]
Albumin was used to study albumin-induced apoptosis in proximal tubule cells.[3] It was also used in cell adhesion molecules and surface treatment studies. [4]

Biochem/physiol Actions

Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influences their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has varied effects on its physiological function.

Other Notes

View more information on human serum albumin.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves