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A5880

Sigma-Aldrich

D-Amphetamine hemisulfate salt

Synonym(s):
(+)-α-Methylphenethylamine hemisulfate salt, Dextroamphetamine hemisulfate salt
Empirical Formula (Hill Notation):
C9H13N · 0.5 H2SO4
CAS Number:
Molecular Weight:
184.25
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: soluble
ethanol: soluble

Featured Industry

Forensics and Toxicology

SMILES string

OS(O)(=O)=O.CC(N)Cc1ccccc1.CC(N)Cc2ccccc2

InChI

1S/2C9H13N.H2O4S/c2*1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2*2-6,8H,7,10H2,1H3;(H2,1,2,3,4)/t2*8-;/m00./s1

InChI key

PYHRZPFZZDCOPH-QXGOIDDHSA-N

Gene Information

human ... SLC18A2(6571)

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Application

D-Amphetamine hemisulfate salt has been used in oxidative fermentative (OF) test, and exploratory test.

Biochem/physiol Actions

D-Amphetamine is an active isomer of amphetamine. It induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites, which blocks catecholamine reuptake.

Certificate of Analysis

Certificate of Origin

Cedric Jackson et al.
Behavioural brain research, 361, 131-138 (2018-12-15)
Although scientific research using mammalian models has made great strides in uncovering the enigmatic neural and molecular mechanisms orchestrating the state of drug addiction, a complete understanding has thus far eluded researchers. The complexity of the task has led to...
J Cartmell et al.
The Journal of pharmacology and experimental therapeutics, 291(1), 161-170 (1999-09-22)
Previous animal studies have indicated that drugs targeted at metabotropic glutamate (mGlu) receptors may be useful for treatment of psychosis. In this article, the effects of the novel, potent, and selective mGlu2/3 receptor agonists LY354740 and LY379268, and the clinically...
Timothy J O'Neal et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(8), 1251-1262 (2019-11-21)
Opioid addiction has been declared a public health emergency, with fatal overdoses following relapse reaching epidemic proportions and disease-associated costs continuing to escalate. Relapse is often triggered by re-exposure to drug-associated cues, and though the neural substrates responsible for relapse...
Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice
Leasure J L, et al.
Environmental Health Perspectives, 116(3), 355-361 (2007)
Yan Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(3), 1217-1222 (2010-01-19)
The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating, a behavior in which central dopamine (DA) has been implicated. Here, we used male prairie voles to examine the effects of drug exposure...

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