A6166

3-Acetyldeoxynivalenol

from Fusarium roseum

• Synonym(s): 3α-Acetoxy-7α,15-dihydroxy-12,13-epoxytrichothec-9-en-8-one, 3α-Acetylvomitoxin, 3-AcDON
• Empirical Formula (Hill Notation): C₁₇H₂₂O₇
• CAS Number: 50722-38-8
• Molecular Weight: 338.35
• MDL number: MFCD00135964
• PubChem Substance ID: 24891062
• NACRES: NA.77

Properties

• biological source: Fusarium roseum
• Quality Level: 200
• storage temp.: 2-8°C
• SMILES string: [H][C@]12O[C@]3([H])[C@@H](C[C@@](C)([C@]34CO4)[C@@]1(CO)[C@H](O)C(=O)C(C)=C2)OC(C)=O
• InChI: 1S/C17H22O7/c1-8-4-11-16(6-18,13(21)12(8)20)15(3)5-10(23-9(2)19)14(24-11)17(15)7-22-17/h4,10-11,13-14,18,21H,5-7H2,1-3H3/t10-,11-,13-,14-,15-,16-,17+/m1/s1
• InChI key: ADFIQZBYNGPCGY-HTJQZXIKSA-N

Description

General description

3-Acetyldeoxynivalenol is a trichothecene mycotoxin, secreted by Fusarium species. It stimulates the activation of c-Jun N-terminal kinase (JNK)/ p38 mitogen-activated protein kinases and prevents protein synthesis. 3-Acetyldeoxynivalenol is a weak inducer of apoptosis.

Application

3-Acetyldeoxynivalenol has been used in a study to compare the ability of two fungi to improve wheat growth, decrease root colonization of Fusarium, and withstand mycotoxins. 3-Acetyldeoxynivalenol has also been used to induce and study anorexia in mice.

Packaging

1, 5 mg in serum bottle

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300 - H311 + H331
• Precautionary Statements: P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Personal Protective Equipment: dust mask type N95 (US),Eyeshields,Gloves
• RIDADR: UN 2811 6.1 / PGII
• WGK Germany: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable