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A6419

Sigma-Aldrich

Adenosine 5′-triphosphate disodium salt hydrate

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

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Synonym(s):
ATP disodium salt
Empirical Formula (Hill Notation):
C10H14N5Na2O13P3 · xH2O
CAS Number:
Molecular Weight:
551.14 (anhydrous basis)
MDL number:
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.75

biological source

microbial

Quality Level

product line

BioReagent

Assay

≥99% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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This Item
A7699A3377A2383
form

powder

form

powder

form

crystalline

form

powder

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL, clear, colorless

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

biological source

microbial

biological source

microbial

biological source

microbial

biological source

microbial

General description

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems. They are released from cells under stress and play a key role in immune response. ATP release from injured neurons and consequent breakdown leads to generation of adenosine. ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain. Elevated ATP levels are indicative of cell damage and inflammation.

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:
  • as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites
  • in inflammasome activation assays in bone marrow derived macrophages
  • for the stimulation of macrophages
  • in nucleotide synthesis

Biochem/physiol Actions

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons
Tullius T, et al.
ScienceOpen Research (2018)
Potential value of adenosine 5?-triphosphate (ATP) and adenosine in anaesthesia and intensive care medicine
Skrabanja ATP, et al.
British Journal of Anaesthesia, 94(5), 556-562 (2005)
Effect of interleukin-31 on septic shock through regulating inflammasomes and interleukin-1beta
Gu X, et al.
Experimental and Therapeutic Medicine, 16(1), 171-177 (2018)
Adenosine and its receptors as therapeutic targets: an overview
Sachdeva S and Gupta M
Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 21(3), 245-253 (2013)
Extracellular ATP and adenosine: the Yin and Yang in immune responses?
Faas MM, et al.
Molecular Aspects of Medicine, 55(5), 9-19 (2017)

Protocols

Separation of Adenosine 5′-triphosphate disodium salt hydrate, BioXtra, ≥99% (HPLC), from microbial; Adenosine 5′-diphosphate sodium salt, bacterial, ≥95% (HPLC); 2′-Deoxyadenosine 5′-monophosphate, Sigma Grade, 98-100%

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