A6419

Adenosine 5′-triphosphate disodium salt hydrate

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

• Synonym(s): ATP disodium salt
• Empirical Formula (Hill Notation): C₁₀H₁₄N₅Na₂O₁₃P₃ · xH₂O
• CAS Number: 34369-07-8
• Molecular Weight: 551.14 (anhydrous basis)
• MDL number: MFCD00150755
• UNSPSC Code: 12352207
• eCl@ss: 32160414
• PubChem Substance ID: 24891086
• NACRES: NA.75

Properties

• biological source: microbial
• Quality Level: 200
• product line: BioReagent
• assay: ≥99% (HPLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C
• SMILES string: O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
• InChI key: NTBQNWBHIXNPRU-MSQVLRTGSA-L

Description

General description

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems.[1] They are released from cells under stress and play a key role in immune response.[2] ATP release from injured neurons and consequent breakdown leads to generation of adenosine.[3] ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain.[1] Elevated ATP levels are indicative of cell damage and inflammation.[4]

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:

• as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites[5]
• in inflammasome activation assays in bone marrow derived macrophages[6]
• for the stimulation of macrophages[7]
• in nucleotide synthesis[8]

Biochem/physiol Actions

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

P₂ purinocepter agonist.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type N95 (US)