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A6751

Sigma-Aldrich

N-Acetyl-L-tyrosine ethyl ester monohydrate

Synonym(s):
ATEE
Empirical Formula (Hill Notation):
C13H17NO4 · H2O
CAS Number:
Molecular Weight:
269.29
Beilstein:
2217900
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Quality Level

assay

≥98%

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O

InChI

1S/C13H17NO4/c1-3-18-13(17)12(14-9(2)15)8-10-4-6-11(16)7-5-10/h4-7,12,16H,3,8H2,1-2H3,(H,14,15)/t12-/m0/s1

InChI key

SKAWDTAMLOJQNK-LBPRGKRZSA-N

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Related Categories

Application

N-Acetyl-L-tyrosine ethyl ester monohydrate has been used:
  • as a substrate in transesterification reactions with 1 M propan-1-ol catalyzed by Carlsberg protease protein-coated microcrystals (PCMC)
  • to test the performance of subtilisin Carlsberg protein-coated microcrystals (PCMC)
  • as a substrate for cross-linked crystals (CLECs) of subtilisin activity screening

Packaging

5, 10, 25 g in poly bottle

Biochem/physiol Actions

N-Acetyl-L-tyrosine ethyl ester is an N-terminal and C-terminal protected L-tyrosine that is used in crosslinking studies and as a substrate for the detection, differentiation and/or characterization various proteases and esterases.

Substrates

Substrate for chymotrypsin

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Operational stability of subtilisin CLECs in organic solvents in repeated batch and in continuous operation
Fernandes JFA, et al.
Biochemical Engineering Journal, 24(1) (24)
Sandra M Arriaga et al.
Clinical biochemistry, 42(9), 919-921 (2009-01-20)
To evaluate if unconjugated bilirubin (UB) inhibits C1 esterase activity. Esterase activity was evaluated by C1-mediated hydrolysis of N-acetyl-L-tyrosine ethyl ester, and binding of UB to C1r and C1s was assessed by dot-blot analysis. UB inhibited C1 enzymatic activity. C1r
Stability of protein-coated microcrystals in organic solvents
Kreiner M, et al.
Journal of Molecular Catalysis. B, Enzymatic, 33(3-6) (33)
Michaela Kreiner et al.
Biotechnology and bioengineering, 87(1), 24-33 (2004-06-24)
Recently, we reported a new high-activity biocatalyst for use in organic media termed protein-coated microcrystals (PCMC) (Kreiner et al. [2001] Chem Commun 12:1096-1097). These novel particles consist of water-soluble micron-sized crystalline particles coated with the given biocatalyst(s) and are prepared
A study of the intermolecular interactions of tolmetin/N-acetyl-L-tyrosine ethyl ester complex.
Tito A, Jimenez-Lopez C, et al.
Spectrochimica Acta Part A: Molecular Spectroscopy, 72, 1000-1006 (2009)

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