A6850

Sigma-Aldrich

Azelaoyl PAF

10 mg/mL in ethanol

Synonym(s):
1-O-Hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine, hexadecyl azelaoyl phosphatidylcholine, 1-O-Hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine
Empirical Formula (Hill Notation):
C33H66NO9P
Molecular Weight:
651.85
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

form

liquid

Quality Level

concentration

10 mg/mL in ethanol

shipped in

wet ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(O)=O)=O)COCCCCCCCCCCCCCCCC)=O

InChI

1S/C33H66NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-23-27-40-29-31(30-42-44(38,39)41-28-26-34(2,3)4)43-33(37)25-22-19-17-18-21-24-32(35)36/h31H,5-30H2,1-4H3,(H-,35,36,38,39)/t31-/m1/s1

InChI key

ZDFOCDTXDPKJKA-WJOKGBTCSA-N

Application

Azelaoyl PAF is a potent PPARγ agonist. Azelaoyl PAF has been used to investigate whether peroxisome proliferator-activated receptors gamma agonists could play a role in the treatment of Friedreich′s ataxia, a neurodegenerative disease due to frataxin deficiency.

Biochem/physiol Actions

Potent PPARγ agonist.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

F

Risk Statement

11

Safety Statement

7-16

RIDADR

UN1170 - class 3 - PG 2 - Ethanol

WGK Germany

WGK 2

Flash Point(F)

57.2 °F - closed cup

Flash Point(C)

14 °C - closed cup

Daniele Marmolino et al.
Cerebellum (London, England), 8(2), 98-103 (2008-12-24)
Friedreich's ataxia is a neurodegenerative disease due to frataxin deficiency, and thus, drugs increasing the frataxin amount are excellent candidates for therapy. By screening Gene Expression Omnibus profiles, we identified records showing a frataxin response to the peroxisome proliferator-activated receptors...

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