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Monoclonal Anti-Actin, Smooth Muscle antibody produced in mouse

~1.0 mg/mL, clone CGA7, purified immunoglobulin, buffered aqueous solution

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MDL number:

biological source


Quality Level



antibody form

purified immunoglobulin

antibody product type

primary antibodies


CGA7, monoclonal


buffered aqueous solution

mol wt

antigen ~42 kDa

species reactivity

rat, chicken, mouse, human, monkey


~1.0 mg/mL


immunocytochemistry: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: 5-10 μg/mL using chicken gizzard total extract



UniProt accession no.

shipped in

dry ice

storage temp.


target post-translational modification


Gene Information

chicken ... ACTA2(423787)
human ... ACTA2(59)
mouse ... Acta2(11475)
rat ... Acta2(81633)

Related Categories

General description

Actin is a highly conserved protein that is a major component of both the cytoskeletal and contractile structures in all cell types. Its expression is related to the type of differentiation and to the functional state of cells and tissues. Actin can be found in two different forms of aggregation, the globular or the fibrillar state, and at least six distinct isoforms occur in vertebrates. The actins exhibit over 90% sequence homology, but each isoform has a unique NH2-terminal sequence. The isoforms are comprised of three alpha actins (skeletal, cardiac, smooth), one beta actin (beta-non-muscle) and two gamma actins (gamma smooth muscle and gamma non-muscle).
Monoclonal Anti-Actin, Smooth Muscle, reacts with human, monkey, chicken, rat, and mouse smooth muscle actin.
Monoclonal Anti-Actin, Smooth Muscle (mouse IgG2b isotype) is derived from the hybridoma CGA7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with partially purified chicken gizzard actin. α-actin 2 (ACTA2) codes for a smooth muscle specific α-actin.
The antibody specifically recognizes α and γ smooth muscle actin.


partially purified chicken gizzard actin.


Monoclonal Anti-Actin, Smooth Muscle antibody produced in mouse has been used in:
  • enzyme-linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunocytochemistry
  • immunohistochemistry

Biochem/physiol Actions

Actin and myosin are constituents of many cell types and are involved in a myriad of cellular processes including locomotion, secretion, cytoplasmic streaming, phagocytosis and cytokinesis. Mutations in alpha-actin 2 (ACTA2) results in thoracic aortic aneurysm, Moyamoya disease, coronary artery disease, stroke and multisystemic smooth muscle dysfunction syndrome. It plays a functional role in the smooth muscle of non-vascular tissues.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids


Not applicable


Not applicable


Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Comparison of human olfactory and skeletal MSCs using osteogenic nanotopography to demonstrate bone-specific bioactivity of the surfaces
Johnstone SA, et al.
Acta Biomaterialia, 13, 266-276 (2015)
Role of fibroblast growth factor signaling during proepicardium formation in the chick embryo
Torlopp A, et al.
Developmental Dynamics, 239(9), 2393-2403 (2010)
ACTA2 mutation and postpartum hemorrhage: a case report
Cooper K and Brown S
BMC Medical Genetics, 18(1), 143-143 (2017)
Romain Lambrot et al.
Journal of andrology, 33(5), 1058-1066 (2012-02-11)
The formation of sperm requires tightly regulated gene expression and unique chromatin remodeling. In the present study, we investigated the spermatogenic distribution of the lysine-specific histone H3 methyltransferase Ezh2 in mice. The distribution of Ezh2 was highly
Beneficial effects of galectin-3 blockade in vascular and aortic valve alterations in an experimental pressure overload model
Ibarrola J, et al.
International Journal of Molecular Sciences, 18(8), 1664-1664 (2017)

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