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A7699

Sigma-Aldrich

Adenosine 5′-triphosphate disodium salt hydrate

BioXtra, ≥99% (HPLC), from microbial

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Synonym(s):
ATP disodium salt
Empirical Formula (Hill Notation):
C10H14N5Na2O13P3 · xH2O
CAS Number:
Molecular Weight:
551.14 (anhydrous basis)
EC Number:
MDL number:
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51

biological source

microbial

Quality Level

product line

BioXtra

assay

≥99% (HPLC)

form

powder

impurities

≤0.1% inorganic P
≤3% solvent content

pKa 

(1) 4.0, (2) 6.5

solubility

H2O: 50 mg/mL, clear, colorless

anion traces

chloride (Cl-): ≤0.05%

cation traces

Al: ≤0.005%
Ca: ≤0.01%
Cu: ≤0.001%
Fe: ≤0.05%
K: ≤0.01%
Mg: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

λmax

259 nm

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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1 of 4

This Item
A3377A2383A26209
solubility

H2O: 50 mg/mL, clear, colorless

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

-

biological source

microbial

biological source

microbial

biological source

microbial

biological source

-

assay

≥99% (HPLC)

assay

≥97% (HPLC)

assay

≥99%

assay

99%

form

powder

form

crystalline

form

powder

form

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Application

Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.

Biochem/physiol Actions

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)


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Stefan P Mortensen et al.
The Journal of physiology, 589(Pt 7), 1847-1857 (2011-02-09)
Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To
Mark W Gorman et al.
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The adenine nucleotide hypothesis postulates that the ATP released from red blood cells is broken down to ADP and AMP in coronary capillaries and that ATP, ADP, and AMP act on purinergic receptors on the surface of capillary endothelial cells.
Alexander Puzenko et al.
The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)
In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy
Shaima'a Hamarsheh et al.
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MARK4 (microtubule affinity-regulating kinase 4) regulates NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3) inflammasome activation. The aim of the study is to examine the role of MARK4 in hematopoietic cells during atherosclerosis. We show increased MARK4

Protocols

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

Separation of Adenosine 5′-triphosphate disodium salt hydrate, BioXtra, ≥99% (HPLC), from microbial; Adenosine 5′-diphosphate sodium salt, bacterial, ≥95% (HPLC); 2′-Deoxyadenosine 5′-monophosphate, Sigma Grade, 98-100%

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