A7980

Sigma-Aldrich

AC-41848 hydrate

≥98% (HPLC), solid

Synonym(s):
1-[(2,4-Dichlorophenyl)methyl]-6,7,8,9-tetrahydro-3-phenyl-5H-imidazo[1,2-a]azepinium bromide hydrate
Empirical Formula (Hill Notation):
C21H21BrCl2N2 · xH2O
Molecular Weight:
452.21 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

storage condition

desiccated
under inert gas

solubility

DMSO: ~14 mg/mL
H2O: >5 mg/mL

storage temp.

2-8°C

SMILES string

[Br-].[H]O[H].Clc1ccc(C[n+]2cc(-c3ccccc3)n4CCCCCc24)c(Cl)c1

InChI

1S/C21H21Cl2N2.BrH.H2O/c22-18-11-10-17(19(23)13-18)14-24-15-20(16-7-3-1-4-8-16)25-12-6-2-5-9-21(24)25;;/h1,3-4,7-8,10-11,13,15H,2,5-6,9,12,14H2;1H;1H2/q+1;;/p-1

InChI key

FPOBEBBUBSFIIA-UHFFFAOYSA-M

Application

AC-41848 is a potent, cell permeable, and subtype selective retinoic acid receptor RARγ agonist.

Packaging

5, 20 mg in glass bottle

Biochem/physiol Actions

AC-41848 is a potent, cell permeable, subtype selective retinoic acid receptor RARγ agonist. AC-41848 has high selectivity (92%) for RARγ. EC50 = 5.9 μM.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Articles
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All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apoptosis, and embryonic development.
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All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apoptosis, and embryonic development.
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