A8094

Sigma-Aldrich

L-Arginine

from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Synonym(s):
(S)-2-Amino-5-guanidinopentanoic acid
Linear Formula:
H2NC(=NH)NH(CH2)3CH(NH2)CO2H
CAS Number:
Molecular Weight:
174.20
Beilstein/REAXYS Number:
1725413
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:

Quality Level

biological source

non-animal source

Agency/Method

USP/NF
meets EP testing specifications
meets USP testing specifications

product line

BioXtra

assay

98.5-101.0%

form

powder

application(s)

cell culture | mammalian: suitable
peptide synthesis: suitable

impurities

endotoxin, tested

color

white

mp

222 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

Featured Industry

Agriculture
Pharmaceutical (small molecule)

SMILES string

N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

InChI key

ODKSFYDXXFIFQN-BYPYZUCNSA-N

Gene Information

human ... NOS1(4842), NOS2(4843)
rat ... Ppm1a(24666)

Looking for similar products? Visit Product Comparison Guide

Application

L-Arginine has been used:
  • as a Roswell park memorial institute medium (RPMI) media component in the isolation and culture of peripheral blood mononuclear cells (PBMCs)
  • as a RPMI media component for tissue culture
  • in DMEM medium for the identification and quantification of phosphorylation sites by stable isotope labeling by amino acids in cell culture (SILAC) and LCMS/MS

Packaging

10 mg in glass bottle
25, 100 g in poly bottle
1 kg in poly bottle

Biochem/physiol Actions

L-Arginine is a conditionally essential amino acid, that play a vital role in the production of nitric oxide. It acts as a precursor for the synthesis of polyamines, agmatine and urea. L-Arginine is usually essential in children and non-essential in adults.
Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells
Boris Shor
The Journal of Biological Chemistry, 285(20), 15380-15392 (2010)
Association of reactive oxygen and nitrogen intermediate and complement levels with apoptosis of peripheral blood mononuclear cells in lupus patients
Oates J C, et al.
Arthritis and Rheumatism, 56(11), 3738-3747 (2007)
J. P. Felix D'Mello
Amino Acids in Human Nutrition and Health, 225-225 (2012)
Cell-specific Labeling Enzymes for Analysis of Cell?Cell Communication in Continuous Co-culture
Tape CJ, et.al.
Molecular and Cellular Proteomics, 13(7), 1866-1876 (2014)
Anti-aging effects of L-arginine
Gad M Z
Journal of Advanced Research, 1(3), 169-177 (2010)
Protocols
XTT assay protocol for measuring cell viability, proliferation, activation and cytotoxicity. Instructions for XTT reagent preparation and examples of applications.
Read More
MTT assay protocol for measuring cell viability, proliferation and cytotoxicity. Instructions for MTT reagent preparation and examples of applications.
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.