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A8849

Sigma-Aldrich

α2-Antiplasmin from human plasma

lyophilized powder, ≥5 units/mg protein

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CAS Number:
MDL number:
NACRES:
NA.77

biological source

human plasma

Quality Level

form

lyophilized powder

specific activity

≥5 units/mg protein

packaging

vial of ≥0.5 mg (Protein based on E1%/280 = 6.7)

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... SERPINF2(5345)

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This Item
SRP6313G0516P1742
α2-Antiplasmin from human plasma lyophilized powder, ≥5 units/mg protein

A8849

α2-Antiplasmin from human plasma

Sigma-Aldrich

P1742

Prealbumin from human plasma

form

lyophilized powder

form

lyophilized

form

lyophilized powder

form

lyophilized powder

Gene Information

human ... SERPINF2(5345)

Gene Information

human ... SERPINF2(5345)

Gene Information

human ... AHSG(197)

Gene Information

human ... TTR(7276)

specific activity

≥5 units/mg protein

specific activity

-

specific activity

-

specific activity

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P08697

UniProt accession no.

P08697

UniProt accession no.

P02765

UniProt accession no.

P02766

General description

α2-Antiplasmin (α2AP) is a glycoprotein and a member of the serine protease inhibitor (serpin) family. The protein is mainly synthesized in the liver and found in the kidney and brain. The serpin peptidase inhibitor, clade F member 2 (SERPINF2) gene is mapped to human chromosome 17p13.3.

Application

α2-Antiplasmin from human plasma has been used as a protease inhibitor to treat human microvascular endothelial cells (HMEC-1) and demonstrate the role of factors responsible for endothelial cells detachment. It has also been used to study its effect on the release of proteolytic activity under reducing conditions in therapeutic human serum albumin-containing products with a new neoepitope endopeptidase immunoassay.

Biochem/physiol Actions

α2-Antiplasmin (α2AP) is an antifibrinolytic protein and an important inhibitor of plasmin. α2AP mediates clot formation by covalently cross-linking with the glutamine and the lysine residue of fibrin clot via activated factor XIII (FXIIIa). This prevents the clot from extreme degradation by plasmin. An inborn insufficiency of α2AP results in an autosomal recessive condition leading to a rare bleeding disorder. The severity of the bleeding condition is defined by the individual′s genetic variation. Studies show lower levels of α2AP associated with disseminated intravascular coagulation (DIC) and thrombolytic therapy. Elevated levels of α2AP have been reported in a patient with ischemic stroke.

Unit Definition

One unit will reduce the activity of two units of plasmin by 50% at 37 °C, pH 7.2, using Val-Leu-Lys-p-nitroanilide.

Physical form

Lyophilized powder containing Bis-tris buffer and NaCl.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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