A8937

Adenosine 5′-triphosphate dipotassium salt hydrate

≥92% (HPLC), microbial, powder

• Synonym(s): ATP, 5′-ATP-K₂
• Empirical Formula (Hill Notation): C₁₀H₁₄K₂N₅O₁₃P₃ · xH₂O
• CAS Number: 42373-41-1
• Molecular Weight: 583.36 (anhydrous basis)
• MDL number: MFCD00084672
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24891383
• NACRES: NA.51

Properties

• Product Name: Adenosine 5′-triphosphate dipotassium salt hydrate, from microbial, ≥92% (HPLC)
• InChI key: YFPSRAQDZYNYPX-IDIVVRGQSA-L
• InChI: 1S/C10H16N5O13P3.2K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
• SMILES string: [K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• biological source: microbial
• assay: ≥92% (HPLC)
• form: powder
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C
• Quality Level: 200

Description

Application

Adenosine 5′-triphosphate dipotassium salt hydrate has been used:

• in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer[1]
• as a component of energy solution for calibrating crude cell extract[2]
• to test its dependency with PK11195 in mediating autophagy[3]

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division.[4] ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP.[5] ATP provides the metabolic energy to drive metabolic pumps.[4] Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.[6]

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems.

Disclaimer

For maximum stability, store as frozen solution at pH 3.5 to 6.8.

General description

Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.[4]

Safety Information

• ppe: dust mask type N95 (US), Eyeshields, Gloves
• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable