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A9041

Sigma-Aldrich

Arg-Gly-Asp-Ser

≥95% (HPLC)

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Empirical Formula (Hill Notation):
C15H27N7O8
CAS Number:
Molecular Weight:
433.42
MDL number:
PubChem Substance ID:
NACRES:
NA.32

biological source

synthetic

Quality Level

assay

≥95% (HPLC)

form

powder

composition

Peptide content, ~70%

technique(s)

cell culture | mammalian: suitable

storage temp.

−20°C

SMILES string

N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O

InChI

1S/C15H27N7O8/c16-7(2-1-3-19-15(17)18)12(27)20-5-10(24)21-8(4-11(25)26)13(28)22-9(6-23)14(29)30/h7-9,23H,1-6,16H2,(H,20,27)(H,21,24)(H,22,28)(H,25,26)(H,29,30)(H4,17,18,19)/t7-,8-,9-/m0/s1

InChI key

NNRFRJQMBSBXGO-CIUDSAMLSA-N

Gene Information

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1 of 4

This Item
G1269A8052T7154
vibrant-m

A9041

Arg-Gly-Asp-Ser

vibrant-m

G1269

Gly-Arg-Gly-Asp-Ser-Pro-Lys

vibrant-m

A8052

Arg-Gly-Asp

vibrant-m

T7154

Tyr-Ile-Gly-Ser-Arg

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (TLC)

assay

≥97% (HPLC)

technique(s)

cell culture | mammalian: suitable

technique(s)

blocking: suitable, ligand binding assay: suitable

technique(s)

cell culture | stem cell: suitable

technique(s)

cell culture | mammalian: suitable

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... ITGA2B(3674), ITGB3(3690)
mouse ... Itgb3(16416)

Gene Information

human ... ITGA2B(3674), ITGAV(3685)

Gene Information

human ... FN1(2335)

Gene Information

-

Amino Acid Sequence

Arg-Gly-Asp-Ser

General description

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.

RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor ß1 (TGFß1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages

Application

Arg-Gly-Asp-Ser has been used:
  • to study its effects on cell attachment in rats
  • to analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptor
  • to pretreat the cells, to assess the role of integrin in the cell attachment process
  • to test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

This product is soluble in water (1 mg/ml), yielding a
clear, colorless solution.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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